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Related Experiment Videos

Intellect after malignancy.

V Twaddle, P G Britton, J Kernahan

    Archives of Disease in Childhood
    |July 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Children treated for leukaemia show intellectual deficits, while those with solid tumours do not. These cognitive deficits in leukaemia survivors remained stable two years later, indicating a potential plateau five years post-diagnosis.

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    Area of Science:

    • Pediatric Oncology
    • Neuropsychology
    • Childhood Cancer Survivorship

    Background:

    • Previous research identified significant intellectual deficits in children treated for leukemia.
    • Children with solid tumors did not exhibit similar intellectual deficits.

    Purpose of the Study:

    • To assess the longitudinal progression of intellectual deficits in childhood leukemia survivors.
    • To compare cognitive outcomes between leukemia survivors and childhood solid tumor survivors over time.

    Main Methods:

    • Longitudinal assessment of intellectual function in pediatric patients.
    • Comparison of cognitive deficits between leukemia and solid tumor treatment groups.

    Main Results:

    • Intellectual deficits observed in leukemia survivors did not worsen over a two-year follow-up period.

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  • No significant intellectual deficits were found in children treated for solid tumors.

    • Conclusions:

    • Cognitive deficits in childhood leukemia survivors appear to stabilize approximately five years after diagnosis.
    • The findings suggest a potential 'nadir' for neurocognitive impairment in this population, with implications for long-term care and support.