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Sorting droplets into many outlets.

Saurabh Vyawahare1, Michael Brundage1, Aleksandra Kijac1

  • 1Verily Life Sciences LLC, 249 E. Grand Avenue, South San Francisco, CA 94080, USA. saurabhv@verily.com.

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|October 7, 2021
PubMed
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This study presents an advanced droplet microfluidic system for high-purity cell sorting. The scalable design integrates novel electrode and fluidic components for precise droplet manipulation and sample recovery.

Area of Science:

  • Biotechnology
  • Microfluidics
  • Cell Sorting

Background:

  • Droplet microfluidics is a mature technology for applications like single-cell sequencing.
  • Integrating droplet making with sorting has faced manufacturing scalability challenges, particularly with injection-molded plastics.

Purpose of the Study:

  • To develop a scalable droplet microfluidic system for high-purity cell sorting.
  • To address limitations in manufacturing and droplet manipulation for droplet-based assays.

Main Methods:

  • A novel electrode design combining metallic and ionic liquid components.
  • A modular, multi-sorting fluidic design ensuring constant inter-droplet distances.
  • Precise actuation of sorting electrodes using fluorescence/scatter signal triggers and timing parameters.

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  • Advanced droplet collection and emulsion breaking techniques for sample recovery.

    • Main Results:

    • Demonstrated a fluorescence-based cell sorter achieving >90% purity.
    • Successfully translated microfluidic designs into injection-molded thermoplastic, suitable for industrial production.
    • Validated the system's capability for precise droplet manipulation and single-droplet collection.

    Conclusions:

    • The developed droplet microfluidic system offers a scalable and high-purity solution for cell sorting.
    • The design innovations overcome previous manufacturing and operational limitations.
    • The technology is suitable for industrial production and downstream biological sample analysis.