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Prostatic tissue: an unexpected finding in a mature ovarian teratoma : Case report and systematic literature review
Irene Pecorella1, Maria Luisa Framarino Dei Malatesta2, Lucia Riganelli2
1Department of Radiological, Oncological and Anatomical Pathology Sciences, University of Rome "Sapienza", Viale Regina Elena 324, 00161, Rome, Italy. irene.pecorella@uniroma1.it.
Purpose:
Prostatic tissue in an ovarian teratoma is an unusual finding, whose initiation in a 46, XX karyotype tissue is yet to be clarified. We present a case from our files and review the literature for this intriguing finding.
Methods:
Unstained histology sections of the ovarian teratoma containing prostatic tissue were evaluated using immunohistochemistry for PSA and androgen receptor.
Results:
Both PSA and androgen receptor immunostainings were positive in the prostatic tissue. From the literature review, it appears that most of the patients (74%) with similar findings were either pregnant or experiencing a miscarriage, menopausal or infertile at presentation, showing that an imbalanced hormone status is frequently associated with the presence of male structures in ovarian teratomas.
