Clear Cell Odontogenic Carcinoma a Systematic Review

Area of Science:

• Oral and Maxillofacial Pathology
• Oncology
• Odontogenic Tumors

Background:

• Clear cell Odontogenic Carcinoma (CCOC) is an uncommon malignant odontogenic tumor, ranking as the fifth most frequent.
• Understanding CCOC's characteristics is crucial for accurate diagnosis and effective management.

Purpose of the Study:

• To conduct a systematic review of Clear cell Odontogenic Carcinoma (CCOC) cases.
• To identify trends in presentation, diagnostic features, treatment modalities, and patient outcomes.
• To analyze demographic, clinical, histopathological, and prognostic factors associated with CCOC.

Main Methods:

• Systematic review of reported cases, case series, and retrospective studies on CCOC.
• Comprehensive database searches to identify relevant literature.
• Analysis of variables including demographics, symptoms, tumor location, histopathology, immunohistochemistry, treatment, follow-up, and recurrence.

Main Results:

• 117 CCOC cases were reviewed, predominantly affecting mature females (65%) with an average age of 55.4 years.
• The mandible, particularly the body (36.2%) and anterior region (23.3%), was the most common tumor site.
• Swelling (80.4%) was the primary clinical sign, often accompanied by pain (41.3%); 97% of cases underwent surgical treatment, with a 52.4% recurrence rate.

Conclusions:

• Clear cell Odontogenic Carcinoma (CCOC) exhibits a predilection for the mandibular body and anterior regions, frequently affecting females.
• Clinical presentation typically involves swelling and can be painful; metastasis is possible.
• Despite surgical intervention, recurrence rates are high, suggesting a fair prognosis for CCOC patients.