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Association between Epstein-Barr virus and periodontitis: A meta-analysis
Chaerita Maulani1, Elza Ibrahim Auerkari2, Sri Lelyati C Masulili3
1Faculty of Dentistry, Doctoral Program, Universitas Indonesia, Jakarta, Indonesia.
Plos One
|October 7, 2021
Summary
Epstein-Barr virus (EBV) significantly increases periodontitis risk, particularly in Asian, European, and American populations. Clinical markers like pocket depth and bleeding on probing are elevated in EBV-positive periodontitis cases.
Area of Science:
- Oral microbiology
- Virology
- Periodontology
Background:
- Epstein-Barr virus (EBV) has been linked to periodontitis, but the association requires further clarification.
- Controversy exists regarding the definitive relationship between EBV and periodontitis severity and clinical indicators.
Purpose of the Study:
- To conduct a meta-analysis to update and clarify the association between Epstein-Barr virus and periodontitis.
- To investigate the correlation between EBV and clinical parameters in periodontitis patients.
Main Methods:
- A systematic literature search was performed in PubMed and Scopus databases.
- A random-effects model was employed for meta-analysis, including odds ratios and confidence intervals.
- Publication bias and sensitivity analyses were conducted to ensure result robustness.
Main Results:
- Twenty-six studies comprising 1354 periodontitis patients and 819 controls were analyzed.
- A significant association was found between EBV detection and periodontitis (OR = 7.069, P<0.001).
- EBV was linked to increased pocket depth and bleeding on probing in periodontitis patients.
Conclusions:
- EBV detection is associated with a higher risk of periodontitis across most populations, except African.
- Nested PCR and multiplex PCR are reliable methods for EBV detection in periodontitis.
- Pocket depth and bleeding on probing serve as reliable clinical indicators of gingival inflammation in EBV-positive periodontitis.
