Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Decision Making01:20

Decision Making

326
Decision-making is a fundamental cognitive process that involves evaluating alternatives and selecting among them. This process can range from simple choices, such as deciding what to wear, to complex decisions, like choosing a major in college or a career path. The complexity of the decision often dictates the approach we use, which can be broadly categorized into two types: automatic and controlled decision-making.
Automatic decision-making is fast, intuitive, and relies on gut feelings...
326
Psychosurgery01:30

Psychosurgery

132
Psychosurgery, the surgical alteration or permanent removal of brain tissue to alleviate severe psychological conditions, stands as one of the most radical and controversial treatments in the history of mental health care. Its development and application have evolved significantly, marked by dramatic shifts in scientific understanding and ethical perspectives.
Historical Development of Psychosurgery
In the 1930s, Portuguese neurologist Antonio Egas Moniz introduced a surgical procedure designed...
132
Reason and Intuition01:37

Reason and Intuition

7.1K
The human brain processes information for decision-making using one of two routes: an intuitive system and a rational system (Epstein, 1994; popularized by Kahneman, 2011 as System 1 and System 2, respectively). The intuitive system is quick, impulsive, and operates with minimal effort, relying on emotions or habits to provide cues for what to do next, while the rational system is logical, analytical, deliberate, and methodical. Research in neuropsychology suggests that the...
7.1K
Antidepressant Drugs: MAOIs and Other Agents01:23

Antidepressant Drugs: MAOIs and Other Agents

436
Atypical antidepressants, including bupropion (Wellbutrin), mirtazapine (Remeron), nefazodone (Serzone), trazodone (Desyrel), and vilazodone (Viibryd), offer unique mechanisms of action. Bupropion weakly inhibits dopamine and norepinephrine reuptake, aiding depression treatment and smoking cessation, with a low risk of sexual dysfunction. Mirtazapine enhances serotonin and norepinephrine neurotransmission, leading to sedation, increased appetite, and weight gain. As a result, it helps treat...
436
Depressive Disorders: Etiology01:27

Depressive Disorders: Etiology

182
Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
182
Ethical Dilemmas II01:30

Ethical Dilemmas II

1.5K
Resolving an ethical dilemma in healthcare involves a systematic approach that considers every aspect of the issue, respecting both the patient's needs and values and the healthcare professional's ethical obligations. Here are potential steps to resolve an ethical dilemma:
1.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Intranasal Esketamine Versus Other Pharmacological Strategies in Treatment-Resistant Depression with High Suicide Risk: A Six-Month Naturalistic Study.

Clinics and practice·2026
Same author

Evaluation of an e-health integrated intervention for pregnant women with co-occurring mental health and substance use symptoms: an exploratory randomized clinical trial.

BMC pregnancy and childbirth·2026
Same author

Effects of Pharmacological and Psychological Treatments on Depressive Symptoms in Body Dysmorphic Disorder: A Systematic Review and Meta-Analysis.

Current psychiatry reports·2026
Same author

Designing interventions guided by digital phenotype and pharmacogenetics in Spain for suicidal behaviour based on retrospective data: the multicentre SMARTomicS study protocol.

BMJ open·2026
Same author

Randomized Controlled Trial on the Effects of Metacognitive Training (MCT) in a Sample of Patients With Recent Onset Psychosis: Study of the Impact on the Severity and Dimensions of Delusions, Self-Esteem and Depression.

Clinical psychology & psychotherapy·2026
Same author

Correction: Full-day sleep pattern analysis in common mental disorders: Leveraging highly discrepant recordings from two consumer tracking devices.

PloS one·2026

Related Experiment Video

Updated: Oct 17, 2025

A New Method for Inducing a Depression-Like Behavior in Rats
07:57

A New Method for Inducing a Depression-Like Behavior in Rats

Published on: February 22, 2018

21.3K

Decision-making in suicidal behavior: A systematic review and meta-analysis.

Aina Sastre-Buades1, Adrián Alacreu-Crespo2, Philippe Courtet3

  • 1Department of Psychiatry, Fundación Jimenez Diaz University Hospital, Madrid, Spain; Department of Neurology, Son Llatzer University Hospital, Palma, Spain.

Neuroscience and Biobehavioral Reviews
|October 7, 2021
PubMed
Summary

Suicide attempters show impaired decision-making (DM) under risky conditions. This cognitive deficit, independent of other factors, suggests a potential trait linked to suicidal vulnerability.

Keywords:
Decision-makingIowa gambling taskSuicidal behaviorSuicideSuicide attempt

More Related Videos

Chronic Stress Shifts Effort-Related Choice Behavior in a Y-Maze Barrier Task in Mice
09:37

Chronic Stress Shifts Effort-Related Choice Behavior in a Y-Maze Barrier Task in Mice

Published on: August 13, 2020

11.5K
Vagus Nerve Stimulation As an Adjunctive Neurostimulation Tool in Treatment-resistant Depression
04:29

Vagus Nerve Stimulation As an Adjunctive Neurostimulation Tool in Treatment-resistant Depression

Published on: January 7, 2019

29.0K

Related Experiment Videos

Last Updated: Oct 17, 2025

A New Method for Inducing a Depression-Like Behavior in Rats
07:57

A New Method for Inducing a Depression-Like Behavior in Rats

Published on: February 22, 2018

21.3K
Chronic Stress Shifts Effort-Related Choice Behavior in a Y-Maze Barrier Task in Mice
09:37

Chronic Stress Shifts Effort-Related Choice Behavior in a Y-Maze Barrier Task in Mice

Published on: August 13, 2020

11.5K
Vagus Nerve Stimulation As an Adjunctive Neurostimulation Tool in Treatment-resistant Depression
04:29

Vagus Nerve Stimulation As an Adjunctive Neurostimulation Tool in Treatment-resistant Depression

Published on: January 7, 2019

29.0K

Area of Science:

  • Neuroscience
  • Psychiatry
  • Cognitive Psychology

Background:

  • Suicidal behavior (SB) is frequently associated with impaired decision-making (DM).
  • Understanding the nuances of DM deficits in SB is crucial for risk assessment and intervention.

Purpose of the Study:

  • To systematically review evidence on DM and its mediating factors in SB.
  • To conduct a meta-analysis on DM performance in individuals with SB using the Iowa Gambling Task (IGT).

Main Methods:

  • Systematic literature search for studies on DM and SB up to 2020.
  • Inclusion of 46 studies for systematic review and 18 for meta-analysis.
  • Meta-analysis compared IGT performance between suicide attempters (SAs) and patients (PCs) or healthy controls (HCs).

Main Results:

  • Systematic review indicated SAs experience difficulties across all DM domains.
  • Meta-analysis revealed significantly worse IGT performance in SAs compared to PCs and HCs.
  • Meta-regression showed no significant differences based on age, gender, psychiatric disorder, or clinical status.

Conclusions:

  • Suicide attempters exhibit DM deficits, particularly under conditions of risk.
  • Impaired DM appears to be a cognitive trait associated with suicidal vulnerability, irrespective of demographic or clinical factors.
  • These findings highlight DM impairment as a potential risk factor and attribute in SAs.