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Production, Characterization and Potential Uses of a 3D Tissue-engineered Human Esophageal Mucosal Model
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Mucus-producing 3D cell culture models.

Maria Helena Macedo1, Ana Baião1, Soraia Pinto1

  • 1i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Rua Alfredo Allen 208, 4200-135 Porto, Portugal; INEB - Instituto de Engenharia Biomédica, Universidade do Porto, Rua Alfredo Allen 208, 4200-135 Porto, Portugal; ICBAS - Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, Rua de Jorge Viterbo Ferreira 228, 4050-313 Porto, Portugal.

Advanced Drug Delivery Reviews
|October 7, 2021
PubMed
Summary
This summary is machine-generated.

Three-dimensional (3D) in vitro models better mimic in vivo tissues than traditional models. This review explores 3D mucus models and their impact on drug delivery research.

Keywords:
3D cell-based modelsDrug absorptionDrug deliveryMucus producing cells

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Area of Science:

  • Biomedical Engineering
  • Pharmacology
  • Cell Biology

Background:

  • In vitro cell models offer cost-effective research tools for drug absorption and disease modeling.
  • Traditional 2D in vitro models often lack the complexity to accurately represent in vivo tissue environments.
  • Mimicking tissue composition and architecture is crucial for reliable experimental outcomes.

Purpose of the Study:

  • To review the impact of mucus on mucosal drug delivery.
  • To provide an overview of current 3D cell-based mucus models.
  • To assess the role of mucus in drug absorption and delivery.

Main Methods:

  • Literature review focusing on 3D in vitro cell models.
  • Analysis of studies incorporating mucus-producing cells.
  • Evaluation of mucus's role in drug absorption and delivery.

Main Results:

  • 3D in vitro models offer enhanced physiological relevance compared to 2D models.
  • Mucus significantly influences drug absorption and delivery across mucosal surfaces.
  • Existing 3D mucus models provide improved platforms for studying drug interactions.

Conclusions:

  • 3D mucus models are essential for accurate prediction of in vivo drug performance.
  • Further development of these models will advance mucosal drug delivery strategies.
  • Understanding mucus's role is critical for optimizing drug formulations.