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Extraction, purification and radioiodination of Khellin as cancer theranostic agent
Adli A Selim1, Basma M Essa2, Islam M Abdelmonem3
1Labeled Compounds Department, Hot Laboratories Centre, Egyptian Atomic Energy Authority (EAEA), Cairo, 13759, Egypt; Radioisotopes Production Facility, Second Egyptian Research Reactor Complex, Egyptian Atomic Energy Authority (EAEA), Cairo, 13759, Egypt.
Abstract:
Khellin was successfully extracted from Ammi visnaga fruits with a recovery percent of 96.15%. Next radio-iodination of Khellin was successfully achieved with a high yield. The biodistribution study of [131I]iodo-khellin in tumour bearing mice revealed that khellin preferentially localization at tumour tissue. Target prediction study for [131I]iodo-khellin revealed that PI3K and VEGFR are potential targets for iodo-khellin with good affinity. The results of this study potentiate [131I]iodo-khellin as a good theranostic agent for tumour imaging and therapy.
