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Cardiovascular Manifestations of Systemic Sclerosis: An Overview of Pathophysiology, Screening Modalities, and

Kyu-In Lee1, Levy Jo Manuntag1, Alina Kifayat2

  • 1From the Department of Medicine, Westchester Medical Center, Valhalla, NY.

Cardiology in Review
|October 7, 2021
PubMed

Insights

Systemic sclerosis (SSc) is a complex disease with significant cardiovascular risks. Early screening and management of SSc-related heart conditions like pulmonary hypertension are crucial for improving patient outcomes.

Area of Science:

  • Cardiology
  • Rheumatology
  • Systemic Sclerosis

Background:

  • Systemic sclerosis (SSc), also known as scleroderma, is characterized by autoantibodies, vasculopathy, and fibroblast dysfunction.
  • Cardiovascular manifestations are a major cause of mortality in SSc patients.
  • Key cardiac issues include electrical conduction abnormalities, pulmonary hypertension, pericardial disease, and atherosclerosis.

Approach:

  • A comprehensive literature review was conducted.
  • The review focused on the cardiovascular manifestations of SSc.
  • The analysis covered definitions, diagnostics, and treatment options for each cardiac complication.

Key Points:

  • Early detection and management of cardiovascular complications in SSc are vital.
  • Annual screening using noninvasive methods is recommended for SSc patients.
  • Treatment strategies for SSc-related cardiac conditions align with general patient management based on clinical severity.

Conclusions:

  • Cardiovascular disease significantly impacts mortality in systemic sclerosis.
  • Proactive screening and timely intervention are essential for managing SSc's cardiac effects.
  • Standard treatment protocols, adapted for SSc, are effective for managing cardiac complications.

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