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Molecular Link between Circadian Rhythmicity and Mood Disorders
Frank Faltraco1, Denise Palm1, Andrew Coogan2
1Department of Psychiatry and Psychotherapy, University Medical Center Rostock, Rostock, Germany.
Current Medicinal Chemistry
|October 8, 2021
Summary
Disruptions in the body's internal clock, regulated by circadian genes and hormones, are molecularly linked to mood disorders. These circadian rhythm disturbances can manifest as depressive symptoms.
Area of Science:
- Neuroscience
- Chronobiology
- Psychiatry
Background:
- The internal biological clock is regulated by circadian genes, hormones, and environmental synchronizers (zeitgebers).
- Chronic disruptions to the circadian rhythm are implicated in various health issues.
Purpose of the Study:
- To review current literature on circadian rhythms in mood disorders.
- To focus on the roles of circadian genes, hormones, and neurotransmitters.
Main Methods:
- A literature review was conducted using the Pubmed database.
- Included articles focused on circadian rhythms and mood disorders, with a publication range from 1973 to 2020.
Main Results:
- A molecular link exists between circadian rhythm disruptions and mood disorders.
- Dysregulation of circadian genes, hormones, and neurotransmitters contributes to mood disturbances.
- Circadian rhythm disturbances can clinically resemble depression.
Conclusions:
- Circadian rhythm disruptions are molecularly linked to mood disorders.
- Dysregulation in circadian mechanisms is associated with depressive symptoms.
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