Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Regional V/Q changes in asthmatics after antigen inhalation.

T Munkner, A Bundgaard

    European Journal of Respiratory Diseases. Supplement
    |January 1, 1986
    PubMed
    Summary

    Allergen inhalation caused significant changes in lung ventilation and blood flow in asthma patients. These ventilation-perfusion defects correlated with reduced peak expiratory flow after antigen-induced asthma.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Effect of respiratory training with a mouth-nose-mask in tetraplegics.

    Paraplegia·1991
    Same author

    A comparative study of the effects of two different doses of nedocromil sodium and placebo given by pressurised aerosol in exercise-induced bronchoconstriction.

    Allergy·1988
    Same author

    Ergogenic effect of inhaled beta 2-agonists in asthmatics.

    International journal of sports medicine·1988
    Same author

    Pulmonary function and acid application in the esophagus.

    Chest·1986
    Same author

    Measurement and regulation of nasal airflow resistance in man.

    Rhinology·1986
    Same author

    Effects of pulmonary inhalation of water and histamine aerosols on nasal airflow resistance in man.

    European journal of respiratory diseases·1986

    Area of Science:

    • Pulmonary medicine
    • Allergy and immunology
    • Medical imaging

    Background:

    • Asthma is a chronic respiratory disease characterized by airway inflammation.
    • Antigen-induced asthma (AIA) involves complex physiological responses.
    • Understanding immediate changes in lung function is crucial for asthma management.

    Purpose of the Study:

    • To investigate the immediate effects of allergen inhalation on regional ventilation and pulmonary blood flow in adults with perennial asthma.
    • To compare these changes with simultaneous alterations in peak expiratory flow.

    Main Methods:

    • Utilized gammacamera imaging with 81mKr (ventilation) and 99mTc-labeled particles (perfusion).
    • Studied five adult patients with perennial asthma undergoing allergen challenge (pollen or moulds).
    • Monitored changes in regional ventilation and perfusion alongside peak expiratory flow.

    Main Results:

    • Observed moderate to profound changes in regional ventilation and pulmonary blood flow post-allergen challenge.
    • Ventilation and perfusion defects were matched in most lung regions.
    • Peak expiratory flow decreased in the majority of patients after AIA.

    Conclusions:

    • Antigen-induced asthma leads to significant, matched regional ventilation-perfusion defects.
    • These immediate functional changes are associated with a decline in lung function as measured by peak expiratory flow.

    Related Experiment Videos