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Regional V/Q changes in asthmatics after exercise.

T Munkner, A Bundgaard

    European Journal of Respiratory Diseases. Supplement
    |January 1, 1986
    PubMed
    Summary
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    Exercise-induced asthma causes irregular ventilation immediately after exercise, but blood flow remains normal. Terbutaline can prevent or treat these ventilatory defects, which differ from histamine-induced issues.

    Area of Science:

    • Pulmonary medicine
    • Respiratory physiology
    • Exercise immunology

    Background:

    • Perennial asthma affects respiratory function.
    • Exercise can trigger asthma symptoms and physiological changes.
    • Understanding immediate post-exercise respiratory changes is crucial for asthma management.

    Purpose of the Study:

    • To investigate immediate changes in regional ventilation and pulmonary blood flow following exercise in adults with perennial asthma.
    • To compare exercise-induced ventilatory defects with those induced by histamine or allergens.
    • To evaluate the efficacy of terbutaline in preventing or treating exercise-induced ventilatory abnormalities.

    Main Methods:

    • Fifteen adults with perennial asthma and two controls underwent moderate exercise (treadmill or bicycle ergometer).

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  • Regional ventilation and pulmonary blood flow were assessed before, immediately after, and 5 minutes post-exercise.
  • Peak expiratory flow was monitored, and terbutaline was administered pre- or post-exercise in some participants.

    • Main Results:

    • Five minutes post-exercise, ventilation became patchy and irregular in asthmatic subjects.
    • Pulmonary blood flow distribution remained normal, similar to the resting state.
    • Terbutaline effectively prevented or resolved these exercise-induced ventilatory defects.
    • Exercise-induced ventilatory defects did not follow a consistent pattern and differed from histamine- or allergen-induced defects.

    Conclusions:

    • Exercise-induced asthma (EIA) leads to transient, irregular regional ventilation post-exercise, while pulmonary blood flow is preserved.
    • Terbutaline demonstrates significant efficacy in managing EIA-related ventilatory disturbances.
    • The pattern of ventilatory defects in EIA is distinct from those caused by other common asthma triggers.