Related Experiment Video
Updated: Oct 17, 2025

Halogenated Agent Delivery in Porcine Model of Acute Respiratory Distress Syndrome via an Intensive Care Unit Type Device
Published on: September 24, 2020
Creation and Implementation of a Hospitalist-Run Propofol Sedation Program
Lisa McAndrew1, Melissa Patel2, Amy Werner2
1Department of Pediatrics mcandrewl@email.chop.edu.
Pediatric hospitalists can safely administer propofol for deep sedation with a standardized training program. This approach led to a low adverse event rate of 3.6% and a high success rate of 98.9% in pediatric patients undergoing MRI.
Area of Science:
- Pediatric hospital medicine
- Sedation and analgesia
- Medical education and training
Background:
- Pediatric hospitalists are increasingly involved in procedural sedation outside the operating room.
- Propofol is a safe and effective agent for deep sedation, supported by extensive safety data.
- Current training for hospitalist-provided sedation varies significantly between institutions.
Purpose of the Study:
- To develop and implement a standardized training program for pediatric hospitalists in the use of propofol for deep sedation.
- To evaluate the safety and efficacy of propofol-based deep sedation administered by trained hospitalists for MRI procedures.
Main Methods:
- A task force developed and implemented a comprehensive training curriculum for hospitalists administering propofol.
- Patient outcomes, including adverse event rates and procedure completion rates, were analyzed retrospectively.
- Adverse events were defined by specific clinical criteria, and successful completion was defined as completing the imaging study or procedure.
Main Results:
- Over a three-year period, 3,929 pediatric patients received deep sedation with propofol administered by trained hospitalists.
- The adverse event rate was 3.6%, with no major complications reported.
- The successful completion rate for imaging studies and procedures was 98.9%.
Conclusions:
- A comprehensive training program enables pediatric hospitalists to safely and effectively administer propofol for deep sedation.
- This standardized approach facilitates the training of new faculty, ensuring consistent, high-quality sedation services.
- Hospitalist-led propofol sedation is a viable option for select pediatric patients undergoing procedures outside the OR.
Related Concept Videos
Parenteral Anesthetics: Overview
Stages of General Anesthesia
Sedatives and Hypnotics: Overview
Sedative-hypnotics are categorized into barbiturates, benzodiazepines (BZDs), and non-benzodiazepines or Z-drugs. These drugs work by suppressing central nervous system activity, and this suppression is dose-dependent. Older sedative medications, like barbiturates, follow a linear curve in...
General Anesthesia: Overview
General anesthesia induces unconsciousness in the whole body, while the others target specific areas or sensations. It is administered to minimize adverse effects, maintain...
Sedatives and Hypnotics Drugs: Miscellaneous Agents
Melatonin congeners like ramelteon (Rozerem) and tasimelteon (Hetlioz) selectively bind to melatonin receptors (MT1 and MT2) and thus mimic the actions of melatonin, a hormone that regulates sleep-wake cycles. Tasimelteon is primarily used for non-24-hour sleep-wake disorder, common in blind patients. They are also used to treat conditions like insomnia...
Management of Insomnia

