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Peripheral Hypertrophic Subepithelial Corneal Degeneration.

Irving M Raber¹, Ralph C Eagle²

¹Cornea Service, Wills Eye Hospital, Philadelphia, PA; and.

|October 8, 2021

Summary

Peripheral hypertrophic subepithelial corneal degeneration (PHSCD) is distinct from Salzmann nodular degeneration (SND). PHSCD presents as peripheral opacities in middle-aged women, often improving with surgery.

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Area of Science:

Ophthalmology
Corneal Diseases
Corneal Degenerations

Background:

Peripheral hypertrophic subepithelial corneal degeneration (PHSCD) is a rare corneal condition.
Differentiating PHSCD from Salzmann nodular degeneration (SND) is clinically important.

Purpose of the Study:

To report a large series of patients with PHSCD.
To differentiate PHSCD from SND based on clinical, refractive, and tomographic findings.

Main Methods:

Retrospective review of 49 patients diagnosed with PHSCD.
Analysis of clinical, refractive, and topographic/tomographic data.
Comparison of PHSCD features with known characteristics of SND.

Main Results:

PHSCD typically presents as peripheral, circumferential, elevated, whitish subepithelial opacities with superficial vessels and iron deposits.
Topographic findings include peripheral flattening over opacities.
Surgical excision improved astigmatism, visual acuity, and patient comfort.

Conclusions:

PHSCD is distinct from SND, characterized by peripheral opacities, occurring in middle-aged women, and often bilateral.
Absence of significant inflammatory signs and symptoms differentiates PHSCD from SND.