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Published on: February 8, 2022
Transcatheter Closure of Perimembranous and Intracristal Ventricular Septal Defects Using Amplatzer Duct Occluder II
Shenrong Liu1, Wenqian Zhang2, Junjie Li1
1Department of Cardiac Pediatrics, Guangdong Cardiovascular Institute, Guangdong Academy of Medical Sciences, Guangdong Provincial People's Hospital, Guangzhou 510080, China.
Insights
The Amplatzer duct occluder II (ADO II) offers a safe and effective transcatheter closure for perimembranous and intracristal ventricular septal defects in children. This minimally invasive approach achieved high success rates with minimal complications in the studied pediatric population.
Area of Science:
- Pediatric Cardiology
- Interventional Cardiology
- Congenital Heart Disease
Background:
- Transcatheter closure of perimembranous (pmVSD) and intracristal (icVSD) ventricular septal defects presents challenges, particularly near the aortic valve.
- Traditional occluders can be difficult to deploy in certain VSD anatomies.
Purpose of the Study:
- To evaluate the safety and efficacy of the Amplatzer duct occluder II (ADO II) for transcatheter closure of pmVSD and icVSD in children.
- To assess procedural success and long-term outcomes.
Main Methods:
- Retrospective analysis of 41 pediatric patients undergoing attempted transcatheter VSD closure with ADO II between March 2014 and June 2020.
- Assessment of implantation success, procedural complications, and follow-up outcomes including closure rates and regurgitation.
Main Results:
- Successful implantation in 97.5% of patients (40/41).
- Complete closure rates of 85.1% for pmVSD and 76.9% for icVSD at median 6-month follow-up.
- One case of transient moderate aortic regurgitation and two cases of tricuspid regurgitation in the pmVSD group; no serious complications in the icVSD group.
Conclusions:
- ADO II is a safe and reproducible option for closing small (<5mm) pmVSD and icVSD in children.
- The device demonstrates good efficacy and a favorable safety profile for pediatric VSD transcatheter closure.
Background:
Transcatheter closure of aneurysmal perimembranous ventricular septal defect (pmVSD), pmVSD near the aortic valve, and intracristal VSD (icVSD) with symmetrical or asymmetrical ventricular septal defect occluders still presents significant challenges. We report our experience with transcatheter closure of pmVSD and icVSD using Amplatzer duct occluder II (ADO II) in children.
Method:
We retrospectively analyzed all children, who presented to our hospital consecutively between March 2014 and June 2020 for attempted transcatheter closure of pmVSD or icVSD with the ADO II device. Standard safety and last-follow-up outcomes were assessed and compared.
Results:
In total, 41 patients underwent transcatheter closure of VSD with the ADO II (28 in pmVSD and 13 in icVSD groups) with a median age of 3.5 years (total range: 0.9 to 12 years) and median weight of 15.0 kg (total range: 10.0 to 43.0 kg). Implantation was successful in 40/41 patients (97.5%, 27/28 in pmVSD group, 13/13 in icVSD group). One patient with mild aortic valve prolapse in pmVSD group developed new-onset moderate aortic regurgitation after a 4/4 mm ADO II was deployed; however, this resolved after the device was retrieved and successfully replaced with a 5 mm zero eccentric VSD occluder. There was no procedure-related mortality. After a median follow-up of six months (total range: 6 to 72 months), complete closure rates were 85.1% and 76.9% among pmVSD and icVSD groups, respectively. In the pmVSD group, one case of new-onset moderate tricuspid regurgitation was observed at six months, and there was one case of severe tricuspid regurgitation that had progressed from mild tricuspid regurgitation at 12 months. No serious complications were noted in the icVSD group.
Conclusion:
ADO II provides a safe and reproducible alternative for the closure of perimembranous and intracristal ventricular septal defects with a diameter less than 5 mm in young children.
