Negative Impact Factors in HIV-Tuberculosis.

Area of Science:

• Public Health
• Infectious Diseases
• Epidemiology

Background:

• Tuberculosis (TB) is a leading infectious cause of death in people living with HIV (HIV-TB coinfection).
• TB treatment outcomes are generally poorer in patients coinfected with HIV.
• This study aimed to identify factors associated with poor TB treatment outcomes in HIV-TB coinfected individuals.

Discussion:

• Retrospective cohort study analyzing data from a local TB registry (2009-2016).
• Included 86 patients with HIV-TB coinfection, with a mean age of 35.05 years.
• Key patient characteristics included high rates of drug use (51.16%) and homelessness (22.10%).

Key Insights:

• Treatment success was achieved in 63.95% of cases; 22.09% died.
• Univariate analysis identified drug use, homelessness, and viral hepatitis as factors associated with poor outcomes.
• Multivariate analysis showed marginal significance for homelessness and drug use, suggesting complex interactions.

Outlook:

• Patients with HIV-TB coinfection, particularly intravenous drug users and those experiencing homelessness, require focused attention.
• Dedicated programs are essential to improve treatment success rates and reduce mortality in this vulnerable population.
• Further research may elucidate specific interventions to mitigate the impact of these risk factors.