Halides as versatile anions in asymmetric anion-binding organocatalysis
Lukas Schifferer1, Martin Stinglhamer1, Kirandeep Kaur1
1Organic Chemistry Institute, Westfälische-Wilhelms University Münster, Correnstraße 36, 48149 Münster, Germany.
Abstract:
This review intends to provide an overview on the role of halide anions in the development of the research area of asymmetric anion-binding organocatalysis. Key early elucidation studies with chloride as counter-anion confirmed this type of alternative activation, which was then exploited in several processes and contributed to the advance and consolidation of anion-binding catalysis as a field. Thus, the use of the halide in the catalyst-anion complex as both a mere counter-anion spectator or an active nucleophile has been depicted, along with the new trends toward additional noncovalent contacts within the HB-donor catalyst and supramolecular interactions to both the anion and the cationic reactive species.
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