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Updated: Oct 17, 2025

Real-time Monitoring of Mitochondrial Respiration in Cytokine-differentiated Human Primary T Cells
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IL-10-Mediated Refueling of Exhausted T Cell Mitochondria Boosts Anti-Tumour Immunity

Dylan Ryan1, Christian Frezza1

  • 1MRC Cancer Unit, University of Cambridge, Cambridge Biomedical Campus, Cambridge CB2 0XZ, UK.

Immunometabolism
|October 8, 2021
PubMed

Immunotherapy has underscored a revolution in cancer treatment. Yet, many patients fail to respond due to T cell exhaustion. Here, an intervention that restores mitochondrial function reversed the exhausted T cell phenotype to promote cytotoxicity and durable anti-tumour responses in vivo.

Keywords:
IL-10T cellexhaustionimmunotherapymetabolismmitochondria

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