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Related Experiment Video

Updated: Oct 17, 2025

Manual Muscle Testing: A Method of Measuring Extremity Muscle Strength Applied to Critically Ill Patients
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Association between Thyroid Dysfunction and Intensive Care Unit-Acquired Weakness: A Case-Control Study.

Tarek Samir Shabana1, Sherif George Anis1, DiaaElDein Mahmoud Ibrahim1

  • 1Faculty of Medicine, Ain Shams University, Cairo, Egypt.

Critical Care Research and Practice
|October 8, 2021
PubMed
Summary
This summary is machine-generated.

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Critically ill patients with lower free T3 (FT3) levels face a higher risk of developing intensive care unit-acquired weakness (ICUAW). This study highlights FT3 as an independent risk factor for ICUAW in the ICU setting.

Area of Science:

  • Critical Care Medicine
  • Endocrinology
  • Neuromuscular Disorders

Background:

  • Thyroid dysfunction, including nonthyroidal illness syndrome (NTIS), is common in critically ill patients.
  • Critically ill patients are susceptible to intensive care unit-acquired weakness (ICUAW).
  • Thyroid disorders may lower the threshold for myopathy development.

Purpose of the Study:

  • To investigate the association between thyroid function abnormalities and the risk of developing ICUAW.
  • To identify thyroid function parameters as independent risk factors for ICUAW.

Main Methods:

  • A case-control study involving 114 ICU patients (57 with ICUAW, 57 without).
  • Assessment of thyroid function tests (free T3, free T4, TSH) in patients admitted for ≥7 days.

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  • Logistic regression analysis to determine independent risk factors for ICUAW.

    • Main Results:

    • Patients with ICUAW had significantly lower free T3 (FT3) levels compared to controls (P=0.004).
    • No significant differences were found in the incidence of euthyroid, hyperthyroid, hypothyroid, or NTIS categories between cases and controls.
    • Multiple regression analysis identified FT3 level as the only independent risk factor for ICUAW (CI=0.157-0.82, P=0.015).

    Conclusions:

    • Lower FT3 levels are inversely associated with the incidence of ICUAW.
    • FT3 may serve as a potential biomarker for predicting ICUAW in critically ill patients.