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Marine Natural Products and Coronary Artery Disease
Bo Liang1, Xin-Yi Cai1, Ning Gu2
1Nanjing University of Chinese Medicine, Nanjing, China.
Insights
Marine natural products show promise for treating coronary artery disease (CAD) by offering new therapeutic avenues. These compounds exhibit antiplatelet, anticoagulant, and lipid-lowering effects, addressing limitations of current CAD pharmacotherapies.
Area of Science:
- Marine natural products
- Drug discovery
- Cardiovascular pharmacology
Background:
- Coronary artery disease (CAD) is a leading cause of global mortality.
- Current pharmacological interventions for CAD have limitations and adverse effects.
- Novel therapeutic strategies are needed for comprehensive CAD management.
Purpose of the Study:
- To explore the potential of marine natural products in treating coronary artery disease.
- To discuss the functions and mechanisms of marine-derived compounds relevant to CAD.
- To highlight marine natural products as a source for new drug development.
Main Methods:
- Literature review of marine natural products with cardiovascular effects.
- Analysis of experimental data on the efficacy of marine compounds.
- Discussion of mechanisms including antiplatelet, anticoagulant, lipid-lowering, anti-inflammatory, and antioxidant activities.
Main Results:
- Marine natural products, including small molecules, polysaccharides, proteins, peptides, and lipids, demonstrate efficacy in treating CAD.
- These compounds possess diverse activities beneficial for CAD management.
- Marine-derived agents offer potential alternatives or adjuncts to existing therapies.
Conclusions:
- Marine natural products represent a promising and chemically diverse resource for novel coronary artery disease drug discovery.
- Their multifaceted biological activities provide a strong foundation for developing new treatments.
- Further research into marine compounds could lead to improved therapeutic options for CAD patients.
Abstract:
Coronary artery disease is the major cause of mortality worldwide, especially in low- and middle-income earners. To not only reduce angina symptoms and exercise-induced ischemia but also prevent cardiovascular events, pharmacological intervention strategies, including antiplatelet drugs, anticoagulant drugs, statins, and other lipid-lowering drugs, and renin-angiotensin-aldosterone system blockers, are conducted. However, the existing drugs for coronary artery disease are incomprehensive and have some adverse reactions. Thus, it is necessary to look for new drug research and development. Marine natural products have been considered a valuable source for drug discovery because of their chemical diversity and biological activities. The experiments and investigations indicated that several marine natural products, such as organic small molecules, polysaccharides, proteins, and bioactive peptides, and lipids were effective for treating coronary artery disease. Here, we particularly discussed the functions and mechanisms of active substances in coronary artery disease, including antiplatelet, anticoagulant, lipid-lowering, anti-inflammatory, and antioxidant activities.
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