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Updated: Oct 17, 2025

Methods for Acute and Subacute Murine Hindlimb Ischemia

Methods for Acute and Subacute Murine Hindlimb Ischemia

Published on: June 21, 2016

Critical lower extremity ischemia after snakebite: A case report.

Zi-Ying Lu¹, Xiao-Dong Wang², Jin Yan¹

¹Department of Vascular Surgery, Tongde Hospital of Zhejiang Province, Hangzhou 310000, Zhejiang Province, China.

World Journal of Clinical Cases

|October 8, 2021

Summary

Snakebites can rarely cause arterial thrombosis, leading to limb ischemia. This case highlights the importance of considering underlying atherosclerotic disease in snakebite patients to prevent severe outcomes.

Keywords:

Case Report Critical extremity ischaemia Haematological abnormalities Snakebite Thrombosis

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Area of Science:

Toxicology
Vascular Surgery
Emergency Medicine

Background:

Snakebites are a significant global health issue, causing millions of cases and thousands of deaths annually.
Common snake envenomation effects include local tissue damage, bleeding disorders, and neurological or kidney toxicity.
Rarer complications, such as thrombosis, can arise, particularly when underlying conditions are present.

Observation:

A 69-year-old male presented with severe right lower extremity pain 10 days post-snakebite.
The patient had no prior history of intermittent claudication or atrial fibrillation.
Imaging revealed acute arterial thrombosis in the right popliteal artery, potentially linked to snakebite-induced coagulopathy and pre-existing atherosclerotic occlusive disease.

Findings:

The patient underwent emergency catheter-directed thrombolysis for acute limb ischemia.
Despite treatment, amputation was necessary due to delayed presentation and irreversible tissue damage.
This case illustrates a rare but severe complication of snakebite.

Implications:

Physicians must consider acute lower extremity ischemia as a rare snakebite complication.
Prompt recognition and management are crucial, especially in patients with underlying atherosclerotic disease.
Awareness of potential coagulopathies and vascular events post-snakebite is essential for effective patient care.