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Streptococcal pneumonia-associated hemolytic uremic syndrome treated by T-antibody-negative plasma exchange in
Xiu-Li Wang1, Yue Du2, Cheng-Guang Zhao1
1Department of Pediatrics, Shengjing Hospital of China Medical University, Shenyang 110004, Liaoning Province, China.
Insights
Streptococcus pneumoniae-associated hemolytic uremic syndrome (SP-HUS) is rising. T-antibody-negative plasma exchange (PE) shows promise in treating severe SP-HUS cases, with pediatric patients achieving full recovery.
Area of Science:
- Pediatric Nephrology
- Infectious Diseases
Background:
- Increasing incidence of Streptococcus pneumoniae-associated hemolytic uremic syndrome (SP-HUS).
- Thomsen-Friedenreich antigen activation plays a key role in SP-HUS pathogenesis.
- T-antibody-negative plasma exchange (PE) is a potential therapeutic option for severe SP-HUS.
Observation:
- Retrospective review of two pediatric SP-HUS cases.
- Detailed clinical and laboratory data were collected.
- Both patients underwent T-antibody-negative PE.
Findings:
- Both pediatric patients experienced a full recovery following repeated PE.
- Patients remained healthy during a 2-year follow-up period.
- Successful treatment outcomes were observed.
Implications:
- Streptococcal pneumonia is an uncommon yet significant cause of HUS.
- T-antibody-negative PE may be a beneficial treatment for SP-HUS patients.
- Further research into PE for SP-HUS is warranted.
Background:
The occurrence of Streptococcus pneumoniae-associated hemolytic uremic syndrome (SP-HUS) is increasing. Thomsen-Friedenreich antigen activation is highly involved in the pathogenesis of SP-HUS, and T-antibody-negative plasma exchange (PE) may be effective in the treatment of severe cases of SP-HUS.
Case Summary:
We retrospectively reviewed two pediatric patients with SP-HUS. Both clinical features and laboratory examination results of the children were described. T-antibody-negative PE was performed in both cases. Both children made a full recovery after repeated PE and remained well at a 2 year follow-up.
Conclusion:
Streptococcal pneumonia continues to be an uncommon but important cause of HUS. The successful treatment of the presented cases suggests that T-antibody-negative PE may benefit patients with SP-HUS.
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