Related Experiment Video
Updated: Oct 17, 2025
06:29
Comparing Objective Conjunctival Hyperemia Grading and the Ocular Surface Disease Index Score in Dry Eye Syndrome During COVID-19
Published on: May 25, 2022
2.5K
Jaundice in patients with COVID-19
Joshua M Bender1,2, Howard J Worman1,2
1Department of Medicine, Vagelos College of Physicians and Surgeons Columbia University New York New York USA.
Summary
Jaundice in patients with coronavirus disease 2019 (COVID-19) indicates a high mortality risk. Sepsis, inflammation, and hypoxic hepatitis are key causes of liver dysfunction leading to jaundice in these patients.
Area of Science:
- Hepatology
- Infectious Diseases
- Critical Care Medicine
Background:
- Liver injury is a known complication of COVID-19.
- The specific impact and causes of hepatic jaundice in COVID-19 patients remain under-investigated.
Purpose of the Study:
- To investigate the clinical outcomes and underlying causes of jaundice in hospitalized COVID-19 patients.
Main Methods:
- Retrospective analysis of 551 COVID-19 patients.
- Defined hepatic jaundice by serum bilirubin levels.
- Characterized liver injury patterns (cholestatic, mixed, hepatocellular).
Main Results:
- Jaundice (8.9%) was linked to significantly higher mortality (40.8%) and ICU admission (69.4%).
- Jaundiced patients exhibited more frequent fever, cytopenias, hypotension, hypoxemia, elevated creatinine, procalcitonin, and sepsis.
- Among those with elevated liver enzymes, cholestatic patterns predominated.
Conclusions:
- Hepatic jaundice is a critical indicator of poor prognosis in COVID-19.
- Sepsis, systemic inflammation, and hypoxic/ischemic hepatitis are primary drivers of liver dysfunction leading to jaundice in COVID-19.
Related Concept Videos
01:14Changes in Skin Color: Clinical Perspectives
2.7K
The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
2.7K
01:26Diseases of the Liver and Gallbladder
1.4K
Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
1.4K
01:28Pleural Effusion II: Symptoms and Management
326
Pleural Effusion Overview
A pleural effusion is the abnormal collection of fluid between the parietal and visceral pleura layers of tissue that form the lining of the lungs and chest cavity. It can occur independently or due to surrounding parenchymal diseases, such as infection, malignancy, or inflammatory conditions.
Clinical Manifestations:
A pleural effusion is the abnormal collection of fluid between the parietal and visceral pleura layers of tissue that form the lining of the lungs and chest cavity. It can occur independently or due to surrounding parenchymal diseases, such as infection, malignancy, or inflammatory conditions.
Clinical Manifestations:
326
01:24Chronic Kidney Disease II: Clinical Manifestations
161
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
161
01:24Nephrotic Syndrome III : Nursing Management
64
Nursing management for nephrotic syndrome adapts as the disease progresses, with strategies evolving to address advancing symptoms and complications.Early-Stage Management In the early stages, nursing interventions for nephrotic syndrome resemble those used in managing acute glomerulonephritis, focusing on symptom monitoring, fluid balance, and managing mild to moderate edema.Vital Signs: Regularly monitor blood pressure, pulse, respiratory rate, and temperature to promptly identify...
64
01:26Nephrotic Syndrome II : Assessment and Medical Management
37
IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document...
37