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Updated: Oct 17, 2025

Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
Published on: May 28, 2014
Photochemistry and in vitro anticancer activity of Pt(IV)Re(I) conjugates
Zhouyang Huang1, A Paden King1, James Lovett2
1Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853, USA. jjw275@cornell.edu.
Abstract:
The photophysical and photochemical properties of two Pt(IV)Re(I) conjugates were studied via both experimental and computational methods. Both conjugates exhibit modest photocytotoxicity against ovarian cancer cells. X-ray fluorescence microscopy showed that Pt and Re colocalize in cells whether they had been irradiated or not. This work demonstrates the potential of photoactivated multilimetallic agents for combating cancer.
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