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Lymph Node Metastases from Visceral Peritoneal Colorectal Metastases are Associated with Systemic Recurrence
Eran Nizri1,2, Yaniv Berger3,4, Eraan Green5
1Peritoneal Surface Malignancy and Melanoma Unit, Department of Surgery A, Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel. eran.nizri@mail.huji.ac.il.
Lymph node metastases from visceral peritoneal colorectal metastases (VPCMs) are associated with higher tumor burden and shorter survival. These findings suggest VPCMs may require adjuvant therapy due to increased systemic recurrence risk.
Area of Science:
- Oncology
- Surgical Oncology
- Gastrointestinal Oncology
Background:
- Visceral peritoneal colorectal metastases (VPCMs) can spread to draining lymph nodes.
- The incidence and prognostic impact of lymph node metastases (LNMs) from VPCMs remain unclear.
Purpose of the Study:
- To investigate the rate, clinical significance, and prognostic value of LNMs in patients with VPCMs.
- To compare outcomes between patients with and without LNMs from VPCMs.
Main Methods:
- Retrospective analysis of 160 patients with VPCMs undergoing cytoreductive surgery and hyperthermic intraperitoneal chemotherapy.
- Identification of 12 patients with LNM-VPCM and comparison of their outcomes with patients without LNM-VPCM.
Main Results:
- Patients with LNM-VPCM exhibited higher tumor burden (PCI) and remnant disease.
- LNM-VPCM was associated with significantly shorter overall survival (22.5 vs. 40.1 months).
- LNM-VPCM correlated with increased systemic recurrence (81.8% vs. 51.6%) but not peritoneal recurrence.
Conclusions:
- Lymph node metastases from VPCMs represent a distinct subgroup with a propensity for systemic recurrence.
- The presence of LNM-VPCM may warrant consideration for adjuvant treatment strategies.
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