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Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
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Combination Therapies and Personalized Medicine02:50

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Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
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Related Experiment Video

Updated: Oct 17, 2025

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?
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Enzymatically Transformable Polymersome-Based Nanotherapeutics to Eliminate Minimal Relapsable Cancer.

Junjie Li1,2, Zhishen Ge1,3, Kazuko Toh2

  • 1CAS Key Laboratory of Soft Matter Chemistry, Department of Polymer Science and Engineering, University of Science and Technology of China, Hefei, Anhui, 230026, China.

Advanced Materials (Deerfield Beach, Fla.)
|October 8, 2021
PubMed
Summary
This summary is machine-generated.

This study introduces a novel nanotherapeutic that targets cancer's postsurgical microenvironment. It effectively reduces cancer recurrence by delivering drugs to eliminate residual tumor cells and premetastatic niches.

Keywords:
bioavailability and toxicityinflammatory microenvironmentminimal residual diseasespostsurgical woundspremetastatic nichestimuli-responsive nanotherapeutics

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Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Oncology

Background:

  • Preventing cancer recurrence after surgery is challenging due to residual tumor cells.
  • Effective drug delivery to minimal residual tumors and the premetastatic niche is limited.

Purpose of the Study:

  • To develop a nanotherapeutic strategy for preventing postsurgical cancer recurrence.
  • To exploit matrix metalloproteinase (MMP) activity for targeted drug delivery.

Main Methods:

  • An enzymatically transformable polymer-based nanotherapeutic system was designed.
  • The system codelivers colchicine and marimastat, activated by MMPs.
  • DePEGylation by MMPs enhances tissue targeting and differential drug release.

Main Results:

  • The nanotherapeutic demonstrated improved bioavailability and retention in tumor-associated tissues.
  • Differential release of drugs targeted extracellular MMPs and intracellular microtubules.
  • Successful disruption of the premetastatic niche and elimination of microresiduals post-surgery.

Conclusions:

  • This nanotherapeutic approach significantly reduces metastatic and local-regional cancer recurrence.
  • The strategy offers a potential therapeutic window for colchicine and MMP inhibitors in inflammatory disorders.