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[Comparative Study of Clinical Manifestations and Sleep Structure in Children with Obstructive Sleep Apnea-hypopnea

Xue-Yun Xu1, Yu-Qing Wang1, Yan-Yu He1

  • 1Department of Respiratory Medicine, Children's Hospital of Soochow University, Suzhou 215003, China.

Sichuan Da Xue Xue Bao. Yi Xue Ban = Journal of Sichuan University. Medical Science Edition
|October 8, 2021
PubMed

Insights

Obesity in children with obstructive sleep apnea-hypopnea syndrome (OSAHS) worsens hypoxia and alters sleep patterns. Overweight and obese children experienced reduced REM sleep and lower oxygen saturation compared to normal weight peers.

Area of Science:

  • Pediatric Pulmonology
  • Sleep Medicine
  • Clinical Research

Background:

  • Obstructive sleep apnea-hypopnea syndrome (OSAHS) is a common condition in children.
  • Body Mass Index (BMI) is a key factor in pediatric health, potentially influencing OSAHS severity.
  • Understanding the impact of different BMI categories on OSAHS clinical manifestations and sleep architecture is crucial for effective management.

Purpose of the Study:

  • To compare and analyze the clinical manifestations and sleep structure of children diagnosed with OSAHS across varying BMI categories.
  • To investigate the relationship between BMI, sleep quality, and respiratory parameters in pediatric OSAHS patients.

Main Methods:

  • A cohort of 452 children diagnosed with OSAHS between 2016 and 2021 underwent polysomnography (PSG).
  • Participants were stratified into normal BMI, overweight, and obese groups based on their BMI.
  • Clinical data and PSG results were collected and analyzed for each group.

Main Results:

  • While clinical manifestations and OSAHS severity did not significantly differ across BMI groups, sleep structure was affected.
  • The obese group exhibited reduced duration and proportion of Rapid Eye Movement (REM) sleep compared to normal and overweight groups.
  • Lowest oxyhemoglobin saturation (LSaO2) was lower in the overweight group, and the oxygen desaturation index (ODI) was higher in the obese group.

Conclusions:

  • Obesity exacerbates hypoxia in children with OSAHS.
  • Increased BMI negatively impacts sleep structure, particularly REM sleep duration, in pediatric OSAHS patients.
  • These findings highlight the critical role of weight management in improving outcomes for children with OSAHS.
Abstract

Keywords:
ChildrenObesityObstructive sleep apnea-hypopnea syndromeSleep structure

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