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A road map to structure-resistance correlations on Mycobacterium tuberculosis MmpL3
Jonathan Bailey1, Luiz Pedro Carvalho2
1Mycobacterial Metabolism and Antibiotic Research Laboratory, The Francis Crick Institute, London NW1 1AT, UK; Discovery Sciences, R&D, AstraZeneca, Cambridge CB4 0WG, UK.
Structure (London, England : 1993)
|October 8, 2021
Abstract:
In this issue of Structure, Adams et al. (2021) present the cryo-EM structure of Mtb MmpL3 and create a structure-based road map of resistance determinants likely to develop in response to clinical use of MmpL3 inhibitors. This structure-resistance correlation map may aid in the development of next-generation antituberculars to circumvent resistance.

