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Restless legs syndrome in pediatric onset multiple sclerosis

Beyza Citci Yalcinkaya1, Ceren Bibinoglu Amirov2, Sema Saltik2

  • 1Acibadem Fulya Hospital, Department of Neurology, Istanbul, Turkey.

Multiple Sclerosis and Related Disorders
|October 8, 2021
PubMed

Insights

Restless Legs Syndrome (RLS/WED) affects 22% of pediatric multiple sclerosis (MS) patients, correlating with higher disease severity. This suggests RLS/WED may be linked to MS progression in young individuals.

Area of Science:

  • Neurology
  • Pediatric Neurology
  • Sleep Medicine

Background:

  • Restless Legs Syndrome/Willis-Ekbom Disease (RLS/WED) is prevalent in adults with Multiple Sclerosis (MS).
  • Pediatric onset Multiple Sclerosis (POMS) is a distinct subtype of MS.
  • Understanding comorbidities in POMS is crucial for comprehensive patient care.

Purpose of the Study:

  • To determine the prevalence of RLS/WED in pediatric patients with MS.
  • To characterize RLS/WED in this young patient population.
  • To explore potential associations between RLS/WED and MS disease parameters.

Main Methods:

  • A cohort of 50 POMS patients were assessed for RLS/WED.
  • Demographic, clinical (including EDSS, MS attacks), and laboratory data were collected.
  • Statistical comparisons were made between POMS patients with and without RLS/WED.

Main Results:

  • RLS/WED was present in 22% of POMS patients, predominantly moderate in severity.
  • Patients with POMS and RLS/WED exhibited significantly higher mean EDSS scores.
  • Elevated IgG index was observed in RLS/WED patients, though not statistically significant.

Conclusions:

  • RLS/WED has a high prevalence in young patients with POMS.
  • Increased disease severity (higher EDSS) in POMS patients with RLS/WED suggests a link.
  • Further research is warranted to elucidate the relationship between RLS/WED and MS pathophysiology.
Abstract

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