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TCR gene-engineered cell therapy for solid tumors

Elaine Tan1, Neel Gakhar2, Kedar Kirtane1

  • 1Moffitt Cancer Center, 12902 USF Magnolia Drive, Tampa, FL, 33612, USA.

Best Practice & Research. Clinical Haematology
|October 9, 2021
PubMed

The engineering of immune cells to target cancer cells (cellular immunotherapy) has been an exciting area of development in recent years. One type of cellular therapy, T cell receptor (TCR) gene engineered therapy, has shown particular promise in solid tumors. Through use of a heterodimer to recognize intracellular tumor antigens presented through the major histocompatibility complex (MHC), TCR T cells are able to evoke a cytotoxic response as well as a clinical response. In this review, we discuss the potential of TCR-based cellular therapies in solid tumors. While various challenges exist with this therapy, multiple clinical trials are ongoing, in attempt to mitigate these limitations.

Keywords:
Cellular therapySolid tumorsTCR

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