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Routine Screening Method for Microparticles in Platelet Transfusions
Published on: January 31, 2018
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Changes in hematological parameters post plateletpheresis: Single center study from North India
Saroj Rajput1, Raj Nath Makroo1, Mohit Chowdhry1
1Department of Transfusion Medicine, Molecular Biology and Transplant Immunology, Indraprastha Apollo Hospital, Delhi-Mathura Road, Sarita Vihar, New Delhi, 110076, India.
Summary
Platelet counts decrease after plateletpheresis donation, but recover within 48 hours. This study confirms donor safety and adequate platelet recovery, supporting frequent donations.
Area of Science:
- Hematology
- Transfusion Medicine
- Donor Management
Background:
- Growing demand for platelet transfusions necessitates increased donor recruitment.
- Evaluating hematological changes post-plateletpheresis is crucial for donor safety and satisfaction.
Purpose of the Study:
- To assess hematological parameter changes in plateletpheresis donors.
- To determine the safety and adequacy of platelet recovery after donation.
Main Methods:
- Analysis of pre- and post-apheresis hematological parameters in 1000 healthy donors over 24 months.
- Observation of platelet recovery in donors returning after 48 hours.
Main Results:
- Significant post-procedure decrease in platelet counts (p<0.001).
- Non-significant declines in hemoglobin, hematocrit, and red blood cells.
- Hematological changes remained within normal limits, with no clinical anemia or thrombocytopenia.
- Platelet recovery observed in 0.03% of donors after 48 hours.
Conclusions:
- Immediate post-donation decrease in platelet count is significant but followed by adequate recovery.
- Platelet collection can be safely performed every 48 hours for donors.
