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Takotsubo (stress) cardiomyopathy after ChAdOx1 nCoV-19 vaccination

Phillip Crane1, Chiew Wong2,3, Nilesh Mehta2

  • 1Department of Cardiology, Northern Health NCHER, Epping, Victoria, Australia phillipgcrane@gmail.com.

BMJ Case Reports
|October 9, 2021
PubMed

Insights

This study details the first known case of takotsubo cardiomyopathy following the ChAdOx1 nCoV-19 vaccine. This finding is crucial for assessing cardiac events after AstraZeneca vaccination.

Area of Science:

  • Cardiology
  • Immunology
  • Public Health

Background:

  • Community vaccination is key to controlling the COVID-19 pandemic.
  • Concerns exist regarding potential vaccine-related adverse events.
  • Thrombotic thrombocytopaenia has been reported post-ChAdOx1 nCoV-19 vaccination.

Observation:

  • A 72-year-old man developed takotsubo cardiomyopathy 4 days after ChAdOx1 nCoV-19 vaccination.
  • Takotsubo cardiomyopathy is typically observed in females.
  • This case presents a novel trigger for the condition.

Findings:

  • The first documented instance of takotsubo (stress) cardiomyopathy after ChAdOx1 nCoV-19 vaccine administration.
  • The patient presented with symptoms of acute coronary syndrome.

Implications:

  • The ChAdOx1 nCoV-19 vaccine may trigger takotsubo cardiomyopathy.
  • Clinicians should consider this adverse event when evaluating patients with acute coronary syndromes post-vaccination.
  • Further research is needed to understand this rare vaccine side effect.

Keywords:
COVID-19Drug interactionsGlobal HealthHeart failureVaccination/immunisation

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