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Pharmacokinetics in Pediatric Patients: Drug Metabolism

Pharmacokinetics in Pediatric Patients: Drug Metabolism

In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses...

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Updated: Oct 17, 2025

One-step Metabolomics: Carbohydrates, Organic and Amino Acids Quantified in a Single Procedure

One-step Metabolomics: Carbohydrates, Organic and Amino Acids Quantified in a Single Procedure

Published on: June 25, 2010

Exploring functional metabolites in preterm infants.

Victoria L Renwick¹, Christopher J Stewart¹

¹Clinical and Translational Research Institute, Newcastle University, Newcastle upon Tyne, UK.

Acta Paediatrica (Oslo, Norway : 1992)

|October 9, 2021

Summary

This summary is machine-generated.

Metabolomics reveals significant changes in preterm infants

Keywords:

late onset sepsis metabolites metabolomics necrotising enterocolitis preterm neonates

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Sample Preparation for Metabolic Profiling using MALDI Mass Spectrometry Imaging

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Published on: December 22, 2020

Area of Science:

Metabolomics and its application in neonatal research.

Background:

Necrotising enterocolitis (NEC) and late onset sepsis (LOS) are leading causes of mortality in preterm infants.
Metabolomics offers insights into cellular functions and health impacts.

Purpose of the Study:

To review and summarize existing literature on metabolomics in preterm infants.
To explore the potential of metabolomics in understanding NEC and LOS.

Main Methods:

Literature review of metabolomic studies in preterm infants.
Analysis of metabolite profiles in serum, urine, and stool.

Main Results:

Limited studies exist, but significant post-partum and first-year metabolite changes are observed.
Associations between metabolite profiles and NEC/LOS are reported, but require larger studies.
Emerging research highlights the role of microbially produced metabolites in infant immunoregulation.

Conclusions:

Metabolomics is a promising field for biomarker discovery in preterm infants.
Further research can enhance understanding of disease processes in preterm neonates.