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Pyroptosis in Kidney Disease

Yujia Wang1, Yinshuang Li1, Yanfang Xu1

  • 1Department of Nephrology, Blood Purification Research Center, the First Affiliated Hospital, Fujian Medical University, Fuzhou 350005, China.

Journal of Molecular Biology
|October 9, 2021
PubMed

Insights

Programmed cell death, including pyroptosis, plays a key role in kidney disease. Understanding pyroptosis mechanisms and GSDMD/GSDME proteins offers new therapeutic strategies for renal injury.

Area of Science:

  • Nephrology
  • Immunology
  • Cell Biology

Background:

  • Apoptosis interference was previously deemed irrelevant in renal injury.
  • Recent discoveries in programmed necrotic cell death (necroptosis, ferroptosis, pyroptosis) have reshaped understanding of cell death in kidney disease.
  • Pyroptosis, a lytic, pro-inflammatory cell death, involves inflammasomes and caspases, leading to DAMPs release and secondary injury.

Purpose of the Study:

  • To review recent advances in the pathological mechanisms of pyroptosis in kidney disease.
  • To highlight potential future therapeutic strategies targeting pyroptosis.

Main Methods:

  • Review of current literature on pyroptosis in kidney disease.
  • Analysis of the roles of caspases, inflammasomes, GSDMD, and GSDME in renal pathology.

Main Results:

  • Pyroptosis is implicated in various acute and chronic kidney diseases.
  • Gasdermin proteins (GSDMD, GSDME) are key effectors in pyroptosis.
  • Uncontrolled release of DAMPs and cytokines from pyroptotic cells drives inflammation and tissue damage.

Conclusions:

  • Pyroptosis is a significant contributor to kidney disease pathogenesis.
  • Targeting pyroptosis pathways presents promising therapeutic avenues for renal injury.
Keywords:
Kidney diseasePyroptosis

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