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Pyroptosis in Kidney Disease.

Yujia Wang¹, Yinshuang Li¹, Yanfang Xu¹

¹Department of Nephrology, Blood Purification Research Center, the First Affiliated Hospital, Fujian Medical University, Fuzhou 350005, China.

Journal of Molecular Biology

|October 9, 2021

Summary

Programmed cell death, including pyroptosis, plays a key role in kidney disease. Understanding pyroptosis mechanisms and GSDMD/GSDME proteins offers new therapeutic strategies for renal injury.

Keywords:

Kidney disease Pyroptosis

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Area of Science:

Nephrology
Immunology
Cell Biology

Background:

Apoptosis interference was previously deemed irrelevant in renal injury.
Recent discoveries in programmed necrotic cell death (necroptosis, ferroptosis, pyroptosis) have reshaped understanding of cell death in kidney disease.
Pyroptosis, a lytic, pro-inflammatory cell death, involves inflammasomes and caspases, leading to DAMPs release and secondary injury.

Purpose of the Study:

To review recent advances in the pathological mechanisms of pyroptosis in kidney disease.
To highlight potential future therapeutic strategies targeting pyroptosis.

Main Methods:

Review of current literature on pyroptosis in kidney disease.
Analysis of the roles of caspases, inflammasomes, GSDMD, and GSDME in renal pathology.

Main Results:

Pyroptosis is implicated in various acute and chronic kidney diseases.
Gasdermin proteins (GSDMD, GSDME) are key effectors in pyroptosis.
Uncontrolled release of DAMPs and cytokines from pyroptotic cells drives inflammation and tissue damage.

Conclusions:

Pyroptosis is a significant contributor to kidney disease pathogenesis.
Targeting pyroptosis pathways presents promising therapeutic avenues for renal injury.