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LDL particle size and antioxidant HDL function improve after sustained virological response in patients with chronic

Jose Ignacio Vargas1, Katherine Rivera2, Marco Arrese1

  • 1Gastroenterology Department, School of Medicine, Pontificia Universidad Católica de Chile, Diagonal Paraguay 362, Santiago, Chile.

Annals of Hepatology
|October 9, 2021
PubMed

Insights

Hepatitis C Virus (HCV) treatment with direct-acting antivirals improved lipid profiles, suggesting a mechanism for reducing cardiovascular disease risk in patients achieving sustained virological response (SVR).

Area of Science:

  • Hepatology
  • Cardiology
  • Virology

Background:

  • Hepatitis C Virus (HCV) infection is linked to a higher risk of cardiovascular events.
  • The specific mechanisms driving this association are not fully understood.
  • Lipid metabolism alterations may play a role in HCV-related cardiovascular complications.

Purpose of the Study:

  • To investigate the impact of direct-acting antiviral (DAA) therapy on lipid profiles in HCV patients.
  • To explore potential mechanisms linking HCV treatment to cardiovascular risk reduction.

Main Methods:

  • Prospective evaluation of 20 HCV patients undergoing DAA treatment.
  • Assessment of lipid parameters, including LDL particle size index (LDL-C/apoB ratio) and HDL antioxidant capacity.
  • Measurements were taken before, during, and after treatment, with follow-up post-treatment.

Main Results:

  • Ninety percent of patients achieved sustained virological response (SVR).
  • A significant increase in LDL particle size index (p=0.023) was observed post-treatment.
  • HDL antioxidant capacity showed significant improvement from baseline, persisting 12 weeks after treatment completion (p=0.001).

Conclusions:

  • Direct-acting antiviral treatment for HCV leads to a less atherogenic lipid profile.
  • Improvements in lipid parameters, particularly LDL particle size and HDL function, may contribute to reduced cardiovascular risk in HCV patients achieving SVR.

Keywords:
Cardiovascular riskDirect-acting antiviralsHDL antioxidant capacityHDL functionalityHepatitis C virusLDL particle sizeSustained virological response

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