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Updated: Oct 17, 2025

RhoC GTPase Activation Assay
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RhoC GTPase Activation Assay

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Role of RhoC in cancer cell migration

Yingyue Lou1, Yuhan Jiang1, Zhen Liang2

  • 1Department of Plastic and Reconstructive Surgery, The First Hospital of Jilin University, Changchun, Jilin, China.

Cancer Cell International
|October 10, 2021
PubMed

Insights

RhoC protein is crucial for cell migration, impacting processes like cancer metastasis. This review details RhoC

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Oncology

Background:

  • Cell migration is a fundamental biological process essential for development and disease.
  • RhoC, a member of the Rho gene family, plays a critical role in regulating cell motility.
  • Dysregulated cell migration is a hallmark of cancer metastasis.

Purpose of the Study:

  • To comprehensively review the multifaceted roles of RhoC in various cell migration processes.
  • To elucidate RhoC's involvement in both 2D and 3D cell migration models.
  • To highlight RhoC's significance in cancer metastasis and identify potential therapeutic targets.

Main Methods:

  • Literature review of studies investigating RhoC function in cell migration.
  • Analysis of RhoC's regulatory mechanisms in 2D cell migration (polarization, adhesion, contraction).
  • Examination of RhoC's role in 3D amoeboid migration, including myosin II regulation.

Main Results:

  • RhoC modulates key events in the 2D cell migration cycle, including cell polarization, adhesion, contraction, and tail retraction.
  • In 3D migration, RhoC regulates myosin II to influence the rate and persistence of amoeba-like movement via membrane vesicle formation.
  • RhoC's function is implicated in the metastasis of numerous cancer types.

Conclusions:

  • This review provides the first comprehensive overview of RhoC's involvement across all cell migration processes.
  • Understanding RhoC-mediated migration is vital for deciphering cancer metastasis mechanisms.
  • Targeting RhoC offers potential for developing novel anti-metastatic therapies and interventions.
Keywords:
AdhesionAmoeboidCell migrationPolarizationRhoCThree-dimensional

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