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Economic impact of Juvenile Idiopathic Arthritis: a systematic review

Fernando García-Rodríguez1, Augusto Gamboa-Alonso2, Sol Jiménez-Hernández1

  • 1Department of Pediatrics, Hospital Universitario "Dr. José E. González", Universidad Autónoma de Nuevo León, Madero y Gonzalitos SN, Col. Mitras Centro, C.P. 64460, Monterrey, Mexico.

Pediatric Rheumatology Online Journal
|October 10, 2021
PubMed

Insights

Juvenile Idiopathic Arthritis (JIA) incurs significant healthcare costs, primarily from medications and appointments. Biological therapies substantially increase these costs, highlighting the economic burden on families.

Area of Science:

  • Rheumatology
  • Health Economics
  • Pediatric Healthcare

Background:

  • Juvenile Idiopathic Arthritis (JIA) presents complex care needs and substantial economic burdens for families.
  • The introduction of biological therapies necessitates an updated understanding of JIA-related healthcare costs.

Purpose of the Study:

  • To systematically review and analyze healthcare costs associated with Juvenile Idiopathic Arthritis (JIA) following the advent of biological therapies.
  • To consolidate and categorize existing data on the economic impact of JIA care.

Main Methods:

  • A comprehensive literature search was conducted across major databases (MEDLINE, EMBASE, Web of Science, Scopus, Cochrane) from January 2000 to March 2021.
  • Included studies reported annual direct and/or indirect costs for JIA patients; costs were standardized to USD and adjusted for inflation.
  • Study quality was assessed by independent reviewers to mitigate bias.

Main Results:

  • Eighteen studies encompassing 6,540 patients were analyzed, revealing annual total costs ranging from $310 to $44,832 USD.
  • Direct costs, predominantly for medications and appointments, constituted 55-98% of total costs ($193-$32,446 USD).
  • Biological therapy initiation led to a threefold increase in total and direct costs; polyarticular JIA showed the highest costs. Reporting bias and methodological inconsistencies were noted.

Conclusions:

  • Healthcare costs for Juvenile Idiopathic Arthritis (JIA) are considerable, with medications and medical appointments being the primary drivers.
  • Indirect costs associated with JIA are frequently underestimated in economic analyses.
  • The economic impact of JIA is significantly amplified by the use of advanced biological treatments.
Abstract

Keywords:
BurdenDirect costsEconomic impactJuvenile Idiopathic ArthritisSystematic review

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