Related Experiment Video

Updated: Oct 17, 2025

Modeling and Evaluation of Murine Diabetic Cardiomyopathy Model
06:22

Modeling and Evaluation of Murine Diabetic Cardiomyopathy Model

Published on: November 29, 2024

874

Heart failure in diabetes

Stanislovas S Jankauskas1, Urna Kansakar1, Fahimeh Varzideh1

  • 1Department of Medicine, Fleischer Institute for Diabetes and Metabolism (FIDAM), Einstein-Mount Sinai Diabetes Research Center (ES-DRC), Albert Einstein College of Medicine, New York, NY 10461, USA; Department of Molecular Pharmacology, Einstein Institute for Neuroimmunology and Inflammation, Wilf Family Cardiovascular Research Institute, Einstein Institute for Aging Research, Albert Einstein College of Medicine, New York, NY 10461, USA.

Metabolism: Clinical and Experimental
|October 10, 2021
PubMed

Insights

Diabetic cardiomyopathy is a major cause of death in diabetes. This review details mechanisms, cellular contributions, preclinical tools, and clinical management updates for this complex heart condition.

Area of Science:

  • Cardiology
  • Endocrinology
  • Pathophysiology

Background:

  • Cardiovascular disorders are the leading cause of mortality in diabetic patients.
  • Diabetic cardiomyopathy (DCM) is a significant complication, contributing to heart failure.
  • Understanding DCM mechanisms is crucial for improving patient outcomes.

Purpose of the Study:

  • To systematically review the primary mechanisms driving diabetic cardiomyopathy development.
  • To elucidate the roles of cardiomyocytes, fibroblasts, endothelial, and smooth muscle cells in diabetic heart failure.
  • To summarize preclinical research tools and recent clinical management strategies for DCM.

Main Methods:

  • Systematic literature review.
  • Analysis of cellular contributions to diabetic cardiomyopathy.
  • Review of preclinical models and clinical trial data.

Main Results:

  • Detailed mechanisms of diabetic cardiomyopathy elucidated.
  • Specific cellular players (cardiomyocytes, fibroblasts, endothelial, smooth muscle cells) identified in disease progression.
  • Overview of available preclinical tools for studying DCM provided.

Conclusions:

  • Diabetic cardiomyopathy involves complex cellular and molecular mechanisms.
  • Preclinical models are essential for dissecting DCM.
  • Current clinical management strategies are evolving with ongoing research.

Keywords:
Adrenergic receptorsAgingBHBBioenergeticsCardiomyocytesCardiovascular endocrinologyDiabetes mellitusDiabetic cardiomyopathyDiastolic dysfunctionEndotheliumFOXO1FibroblastsFibrosisHFpEFHeart failureMitochondriaNADHOxidative stressROSSenescenceT1DMT2DMVSMC

More Related Videos

Mouse Electroacupuncture Fixation Device Fabrication for Electroacupuncture Pretreatment in Diabetic Cardiomyopathy Mouse Model05:58

Mouse Electroacupuncture Fixation Device Fabrication for Electroacupuncture Pretreatment in Diabetic Cardiomyopathy Mouse Model

Published on: April 18, 2025

345
Author Spotlight: Investigating HR-Dependent Cardiac Function in Mouse Models Through a Novel Atrial-Pacing Approach07:49

Author Spotlight: Investigating HR-Dependent Cardiac Function in Mouse Models Through a Novel Atrial-Pacing Approach

Published on: July 21, 2023

1.6K

Related Concept Videos

Heart Failure I: Introduction01:27

Heart Failure I: Introduction

Heart failure refers to a clinical syndrome caused by structural or functional cardiac disorders that prevent the heart from pumping an adequate amount of blood to meet the body's metabolic needs. This condition often arises from myocardial infarction or ischemia, leading to decreased cardiac output, reduced tissue perfusion, impaired gas exchange, fluid volume imbalance, and decreased functional ability.Heart failure can result from disruptions in the mechanisms that regulate cardiac output...
151
Pathophysiology of Heart Failure01:17

Pathophysiology of Heart Failure

Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
2.0K
Heart Failure VII: Nursing Interventions01:30

Heart Failure VII: Nursing Interventions

The first step in nursing management of a patient with heart failure involves thoroughly assessing the patient's medical history.Subjective Data: Obtain the patient's medical history of coronary artery disease, hypertension, myocardial infarction, and symptoms like dyspnea, orthopnea, and paroxysmal nocturnal dyspnea.Objective Data: Conduct a physical examination to identify findings such as jugular vein distention, pulmonary crackles, tachycardia, murmurs, peripheral edema, and vital signs,...
190
Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
103
Heart Failure III: Clinical Manifestations01:26

Heart Failure III: Clinical Manifestations

Heart failure (HF) manifests primarily as dyspnea, fatigue, and fluid retention, resulting in peripheral and pulmonary edema. Symptoms may vary depending on which ventricle is more affected, left or right.Left-Sided Heart FailureAlso known as left ventricular failure, this condition results from the left ventricle's inability to fill or eject sufficient blood into the systemic circulation. It leads to pulmonary congestion, which occurs when the left ventricle fails to eject blood effectively...
91
Heart Failure Drugs: Diuretics01:22

Heart Failure Drugs: Diuretics

Heart failure and kidney perfusion are interconnected in a complex way. Reduced renal perfusion and venous congestion are two significant factors that contribute to renal dysfunction in heart failure. The kidneys, primarily responsible for fluid balance in the body, are adversely affected due to compromised cardiac output and increased venous pressure. In response to reduced renal perfusion, the kidneys activate neurohumoral mechanisms to restore balance. However, these mechanisms can be...
532