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Related Experiment Video

Updated: Oct 17, 2025

Large-scale Three-dimensional Imaging of Cellular Organization in the Mouse Neocortex
09:55

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Published on: September 5, 2018

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A TRPV6 expression atlas for the mouse.

Philipp Wartenberg1, Femke Lux1, Kai Busch1

  • 1Department of Experimental and Clinical Pharmacology and Toxicology, Center for Molecular Signaling (PZMS), Saarland University School of Medicine, Homburg, Germany.

Cell Calcium
|October 10, 2021
PubMed
Summary
This summary is machine-generated.

This study maps the expression of the calcium-selective TRPV6 channel in mice. Understanding TRPV6 distribution is key to its role in calcium balance and physiological functions.

Keywords:
BladderBoneCecumCre recombinaseDuodenumEpididymisGenetic labelingIleumJejunumMass spectrometryPancreasProstateReproductive systemSalivary glandTRPV6TeethTongueUterus

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Area of Science:

  • Physiology
  • Molecular Biology
  • Genetics

Background:

  • The transient receptor potential vanilloid 6 (TRPV6) channel is crucial for calcium (Ca2+) transport and homeostasis.
  • A comprehensive understanding of TRPV6 expression patterns is essential for elucidating its physiological roles.

Purpose of the Study:

  • To create a detailed organism-wide expression atlas of the TRPV6 channel in mice.
  • To identify primary TRPV6-expressing cells and map their distribution.

Main Methods:

  • Utilized a novel murine Trpv6-reporter strain to identify TRPV6-expressing cells.
  • Employed TRPV6 immunoprecipitation followed by mass spectrometry in wild-type mice.
  • Correlated reporter gene expression with mass spectrometry data.

Main Results:

  • Generated a comprehensive TRPV6 expression atlas for juvenile and adult mice.
  • Identified specific cell populations and tissues with significant TRPV6 expression.
  • Validated expression patterns through complementary experimental approaches.

Conclusions:

  • Presents a valuable resource for in vivo research on TRPV6 function.
  • Provides foundational data for investigating TRPV6's role in calcium homeostasis and related physiological processes.
  • Highlights the utility of reporter strains and mass spectrometry for mapping protein expression.