Related Experiment Video
Updated: Oct 17, 2025
Porcine Liver Transplantation Without Veno-Venous Bypass As an Extended Criteria Donor Model
Published on: August 17, 2022
Risk factors analysis of hyperbilirubinemia after off-pump coronary artery bypass grafting: a retrospective
Yingdi Gao1, Dongjie Li1, Honghong Dong2
1Department of Cardiac Surgery, Heart Center and Beijing Key Laboratory of Hypertension, Beijing Chaoyang Hospital, Capital Medical University, No. 8 Gong Ti South Road, Chaoyang District, Beijing, 100020, China.
Insights
Postoperative hyperbilirubinemia occurred in 7.7% of patients after off-pump coronary artery bypass grafting (OPCAB). Elevated preoperative bilirubin, blood transfusion, and intra-aortic balloon pump (IABP) implantation were identified as independent risk factors.
Area of Science:
- Cardiology
- Surgical Complications
- Hepatic Function
Background:
- Hyperbilirubinemia is a frequent complication following off-pump coronary artery bypass grafting (OPCAB).
- The precise incidence and contributing risk factors for this complication remain incompletely understood.
- This study investigates the occurrence and determinants of postoperative hyperbilirubinemia in OPCAB patients.
Purpose of the Study:
- To determine the incidence of postoperative hyperbilirubinemia in patients undergoing OPCAB.
- To identify independent risk factors associated with the development of hyperbilirubinemia post-OPCAB.
- To provide data for potential preventative strategies and improved patient management.
Main Methods:
- A retrospective analysis of 416 consecutive patients undergoing OPCAB from December 2016 to March 2019.
- Patients were categorized into normal serum total bilirubin and hyperbilirubinemia groups.
- Univariate and multivariate logistic regression analyses were employed to identify risk factors.
Main Results:
- The incidence of postoperative hyperbilirubinemia was 7.7% (32 out of 416 patients).
- Significant differences between groups included gender, preoperative total bilirubin levels, and perioperative use of intra-aortic balloon pump (IABP) and blood transfusion.
- Multivariate analysis identified elevated preoperative serum total bilirubin, perioperative blood transfusion, and perioperative IABP implantation as independent risk factors (P < 0.001).
Conclusions:
- Postoperative hyperbilirubinemia is a notable complication after OPCAB.
- Elevated preoperative bilirubin, perioperative blood transfusion, and IABP implantation are key independent risk factors.
- Further research is warranted to validate these findings and explore clinical implications.
Background:
Hyperbilirubinemia is a common complication after off-pump coronary artery bypass grafting (OPCAB), but the incidence and the risk factors are unclear. This study aimed to analyze the incidence and risk factors of postoperative hyperbilirubinemia in patients undergoing OPCAB.
Methods:
From December 2016 to March 2019, a total of 416 consecutive patients undergoing OPCAB were enrolled in this single-center retrospective study. Patients were divided into the normal serum total bilirubin group and the hyperbilirubinemia group based on the serum total bilirubin levels. Perioperative variables between the two groups were compared by univariate logistic regression analysis. Then, multivariate binary logistic regression analysis was used to analyze the independent risk factors of developing hyperbilirubinemia in patients underwent OPCAB. P < 0.05 was considered as statistically significant.
Results:
Thirty two of 416 (7.7%) patients developed postoperative hyperbilirubinemia. Univariate regression analysis showed significant differences in gender (73.96% vs. 93.75%, P = 0.012), preoperative total bilirubin levels (11.92 ± 4.52 vs. 18.28 ± 7.57, P < 0.001), perioperative IABP implantation (22.66% vs. 43.75%, P = 0.008), perioperative blood transfusion (37.50% vs. 56.25%, P = 0.037) between the two groups. Multivariate logistic regression analysis revealed that elevated preoperative serum total bilirubin levels (OR = 1.225, 95% CI 1.145-1.310, P < 0.001), perioperative blood transfusion (OR = 4.488, 95% CI 1.876-10.737, P = 0.001) and perioperative IABP implantation (OR = 4.016, 95% CI 1.709-9.439, P = 0.001) were independent risk factors for hyperbilirubinemia after OPCAB.
Conclusions:
Hyperbilirubinemia is also a common complication after OPCAB. Elevated preoperative serum total bilirubin levels, perioperative blood transfusion, and perioperative IABP implantation were independent risk factors for patients developing hyperbilirubinemia after OPCAB. Further studies need to be conducted to confirm the risk factors of hyperbilirubinemia after OPCAB procedure.
