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Immunization-Associated Corneal Transplantation Rejection: A Review
1Department of Ophthalmology and Vision Science, University of California, Davis, Sacramento CA.
Cornea
|October 11, 2021
Summary
Immunization may rarely trigger corneal graft rejection, particularly after influenza vaccination. While uncommon, patients and surgeons should be aware of this potential risk, necessitating further reporting.
Area of Science:
- Ophthalmology
- Immunology
- Transplantation
Background:
- Corneal transplantation is a common procedure to restore vision.
- Graft rejection remains a significant complication following corneal transplantation.
- The role of immunization in triggering corneal graft rejection is not well-established.
Purpose of the Study:
- To review and characterize existing literature on immunization-associated corneal graft rejection.
- To identify patterns and potential risk factors associated with this rare complication.
Main Methods:
- A comprehensive literature search was performed using PubMed.
- Keywords included corneal transplantation, graft rejection, and immunization.
- Nine relevant studies published up to July 2021 were included for analysis.
Main Results:
- Twenty-three cases of corneal graft rejection temporally linked to immunizations were identified.
- The majority of affected patients were female and had received the influenza vaccine prior to rejection.
- Intensive corticosteroid therapy was effective in preserving most grafts.
Conclusions:
- Immunization-associated corneal graft rejection is a rare but potentially underreported event.
- Awareness among patients and surgeons is advised, though evidence remains inconclusive.
- The small sample size and retrospective nature of studies limit definitive conclusions; reporting is encouraged.
