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The Association between Thyroid-Stimulating Hormone and Long-Term Outcomes in Patients with ST Segment Elevation

Yuansong Zhu1, Jian Shen1, Yuzhou Xue1

  • 1Department of Cardiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People's Republic of China.

International Journal of General Medicine
|October 11, 2021
PubMed

Insights

Elevated thyroid-stimulating hormone (TSH) levels above 3.5 mIU/L are linked to worse long-term survival in ST-elevation myocardial infarction (STEMI) patients. Normal or low TSH levels did not impact long-term outcomes after STEMI.

Area of Science:

  • Cardiology
  • Endocrinology
  • Internal Medicine

Background:

  • Thyroid hormones play a crucial role in cardiovascular function.
  • Understanding the impact of thyroid-stimulating hormone (TSH) on acute myocardial infarction outcomes is vital.

Purpose of the Study:

  • To investigate the association between admission TSH levels and long-term mortality in ST-segment elevation myocardial infarction (STEMI) patients.
  • To stratify STEMI patient outcomes based on admission TSH levels.

Main Methods:

  • 1186 STEMI patients were categorized into four TSH groups: <0.35, 0.35-1.0, 1.0-3.5, and >3.5 mIU/L.
  • All-cause mortality was assessed over a median follow-up of 2.5 years.
  • Cox proportional hazard regression models were used to determine prognostic factors.

Main Results:

  • Patients with TSH >3.5 mIU/L exhibited higher blood pressure and the worst long-term outcomes.
  • A significantly lower cumulative survival was observed in the TSH >3.5 mIU/L group.
  • TSH >3.5 mIU/L was identified as an independent risk factor for long-term mortality post-STEMI.

Conclusions:

  • Elevated TSH levels (>3.5 mIU/L) are associated with poorer long-term prognosis in STEMI patients.
  • TSH levels within the normal range or below normal did not significantly affect long-term survival.
  • Admission TSH >3.5 mIU/L serves as an independent predictor of mortality following STEMI.
Abstract

Keywords:
STEMITSHacute myocardial infarctionthyroid hormonethyroid-stimulating hormone

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