Treatment of recurrent, filarial, Calabar-type oedema with mebendazole

A case of recurrent, severe filarial Calabar-type oedema, causing acute discomfort in the patient, is described in a male Caucasian. An adult Loa loa worm but no microfilariae were present while Dipetalonema perstans microfilaraemia was extremely low. Treatment with mebendazole (1.5 g per day) for 21 days led to the disappearance of the clinical symptoms and microfilariae, and to a decrease of eosinophilia to normal values.