Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Potential of Trichloroacetic Acid in Smear Layer and Calcium Hydroxide Removal in Root Canals-Exploratory Pilot Studies In Vitro.

International dental journal·2026
Same author

Retraction notice to "Long noncoding RNA TUG1 promotes osteogenic differentiation of human periodontal ligament stem cell through sponging microRNA-222-3p to negatively regulate Smad2/7" [Archives of Oral Biology 117 (2020) 104814].

Archives of oral biology·2026
Same author

Minimally Invasive Endodontic Treatment through the Labial/Buccal Cervical Approach - Protocol and Case Series.

Journal of endodontics·2025
Same author

Water-soluble polysaccharides extracted from Enteromorpha prolifera/PVA composite film functionalized as ε-polylysine with improved mechanical and antibacterial properties.

International journal of biological macromolecules·2024
Same author

Corrigendum to "Synergistic and antibiofilm activity of DNase I and glucose oxidase loaded chitosan nanoparticles against dual-species biofilms of Listeria monocytogenes and Salmonella" [Int. J. Biol. Macromol. 269(Part 2) (June 2024) 131943].

International journal of biological macromolecules·2024
Same author

Synergistic and antibiofilm activity of DNase I and glucose oxidase loaded chitosan nanoparticles against dual-species biofilms of Listeria monocytogenes and Salmonella.

International journal of biological macromolecules·2024
Same journal

Correction to "Mathematical Modelling of COVID-19 Transmission in Kenya: A Model with Reinfection Transmission Mechanism".

Computational and mathematical methods in medicine·2025
Same journal

RETRACTION: Ligustrazine Inhibits Lung Phosphodiesterase Activity in a Rat Model of Allergic Asthma.

Computational and mathematical methods in medicine·2025
Same journal

RETRACTION: Delivery of miR-224-5p by Exosomes from Cancer-Associated Fibroblasts Potentiates Progression of Clear Cell Renal Cell Carcinoma.

Computational and mathematical methods in medicine·2025
Same journal

RETRACTION: Empirical Analysis of the Nursing Effect of Intelligent Medical Internet of Things in Postoperative Osteoarthritis.

Computational and mathematical methods in medicine·2025
Same journal

RETRACTION: Evaluation and Analysis of the Intervention Effect of Systematic Parent Training Based on Computational Intelligence on Child Autism.

Computational and mathematical methods in medicine·2024
Same journal

RETRACTION: Humanistic Spirit Training of Medical Students Based on Multisource Medical Data Fusion.

Computational and mathematical methods in medicine·2024
See all related articles

Related Experiment Video

Updated: Oct 17, 2025

Author Spotlight: Enhancing Dental Pulp Research with Improved Mouse Models
05:16

Author Spotlight: Enhancing Dental Pulp Research with Improved Mouse Models

Published on: October 27, 2023

1.3K

Identification of Pulpitis-Related Potential Biomarkers Using Bioinformatics Approach.

Bingchang Xin1, Yuxiang Lin2,3, He Tian2,3

  • 1Department of Cariology and Endodontology, Qingdao Stomatological Hospital Affiliated to Qingdao University, 266001 Qingdao, Shandong Province, China.

Computational and Mathematical Methods in Medicine
|October 11, 2021
PubMed
Summary
This summary is machine-generated.

This study identified four key genes as potential biomarkers for pulpitis severity. These genes are upregulated in pulpitis and coexpressed with chemokine-related genes, offering new diagnostic possibilities.

More Related Videos

Performing Data Mining And Integrative Analysis Of Biomarker in Breast Cancer Using Multiple Publicly Accessible Databases
07:41

Performing Data Mining And Integrative Analysis Of Biomarker in Breast Cancer Using Multiple Publicly Accessible Databases

Published on: May 17, 2019

9.2K
Author Spotlight: Unveiling Transmembrane Protein Family-Related Markers in Gastric Cancer and Implications for Targeted Therapies
07:47

Author Spotlight: Unveiling Transmembrane Protein Family-Related Markers in Gastric Cancer and Implications for Targeted Therapies

Published on: September 15, 2023

1.8K

Related Experiment Videos

Last Updated: Oct 17, 2025

Author Spotlight: Enhancing Dental Pulp Research with Improved Mouse Models
05:16

Author Spotlight: Enhancing Dental Pulp Research with Improved Mouse Models

Published on: October 27, 2023

1.3K
Performing Data Mining And Integrative Analysis Of Biomarker in Breast Cancer Using Multiple Publicly Accessible Databases
07:41

Performing Data Mining And Integrative Analysis Of Biomarker in Breast Cancer Using Multiple Publicly Accessible Databases

Published on: May 17, 2019

9.2K
Author Spotlight: Unveiling Transmembrane Protein Family-Related Markers in Gastric Cancer and Implications for Targeted Therapies
07:47

Author Spotlight: Unveiling Transmembrane Protein Family-Related Markers in Gastric Cancer and Implications for Targeted Therapies

Published on: September 15, 2023

1.8K

Area of Science:

  • Dental research
  • Molecular biology
  • Biomarker discovery

Background:

  • Pulpitis involves inflammatory reactions crucial for pathogen elimination and tissue repair.
  • Traditional methods for evaluating pulpitis severity have significant limitations.
  • Identifying reliable biomarkers is essential for effective therapeutic strategies.

Purpose of the Study:

  • To identify novel molecular biomarkers for assessing pulpitis severity.
  • To analyze differentially expressed genes (DEGs) associated with pulpitis.
  • To uncover key genes and pathways involved in pulpitis pathogenesis.

Main Methods:

  • Utilized the Gene Expression Omnibus (GEO) database to identify 843 DEGs in pulpitis.
  • Constructed a protein-protein interaction (PPI) network and performed functional enrichment analyses (GO, KEGG).
  • Employed network analysis (MCODE, RWR) and GeneMANIA to identify four hub genes and their coexpressed genes.

Main Results:

  • DEGs were significantly enriched in inflammatory reaction-related functions.
  • Four hub genes were identified through integrated network analysis.
  • These four hub genes showed remarkable upregulation in the pulpitis group and coexpression with chemokine-related genes.

Conclusions:

  • Four hub genes were identified as potential diagnostic biomarkers for pulpitis.
  • The findings highlight the role of these genes in pulpitis pathogenesis and inflammation.
  • This research provides a foundation for developing improved diagnostic tools for pulpitis.