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Related Concept Videos

Synthesis and Regulation of Thyroid Hormones01:20

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Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients
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Relationship between Different Psoriasis Types and Thyroid Dysfunction: A Retrospective Analysis.

Juan Du1, Chunyue Ma2, Runnan Wang3

  • 1Department of Dermatology, Huashan Hospital, Fudan University, Shanghai 200040, China.

Scanning
|October 11, 2021
PubMed
Summary

Psoriasis is linked to thyroid dysfunction, particularly in atypical forms like erythrodermic psoriasis. Erythrodermic patients may experience decreased thyroid hormones, warranting careful monitoring for complications.

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Area of Science:

  • Endocrinology
  • Dermatology
  • Immunology

Background:

  • Psoriasis is a chronic inflammatory skin condition.
  • Thyroid dysfunction is common in autoimmune diseases.
  • The relationship between specific psoriasis types and thyroid function requires further investigation.

Purpose of the Study:

  • To investigate the association between different types of psoriasis and thyroid dysfunction.
  • To analyze thyroid hormone and antibody levels across various psoriasis subtypes.

Main Methods:

  • Retrospective analysis of 468 patients diagnosed with psoriasis between 2013 and 2018.
  • Measurement of thyroid function tests including free triiodothyronine (FT3), free thyroxine (FT4), total triiodothyronine (TT3), total thyroxine (TT4), thyroid-stimulating hormone (TSH), thyroglobulin antibody (TGAb), and thyroid peroxidase antibody (TPOAb).
  • Comparison of thyroid function parameters among patients with psoriasis vulgaris, pustular psoriasis, erythrodermic psoriasis, and psoriatic arthritis.

Main Results:

  • Psoriasis vulgaris patients showed a higher proportion of normal thyroid hormone levels.
  • Erythrodermic psoriasis patients were more likely to have decreased FT3 or FT4 with normal TSH.
  • Pustular psoriasis patients had lower FT3 levels, erythrodermic patients had lower FT4 levels, and psoriatic arthritis patients had higher TSH levels. TPOAb levels were elevated in all patients, but without significant differences among types.

Conclusions:

  • Psoriasis is associated with thyroid dysfunction, especially in atypical presentations.
  • Erythrodermic psoriasis warrants consideration for potential thyroid complications.
  • Further research into the mechanisms linking psoriasis and thyroid dysfunction is recommended.