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Liver Kidney Crosstalk: Hepatorenal Syndrome
Mahmoud Nassar1, Nso Nso1, Luis Medina1
1Department of Medicine, Icahn School of Medicine at Mount Sinai / NYC Health + Hospitals / Queens, New York, NY 11432, United States.
World Journal of Hepatology
|October 11, 2021
Summary
Hepatorenal syndrome (HRS) involves kidney dysfunction caused by liver disease. This review covers HRS epidemiology, pathophysiology, diagnosis, and management for better understanding and treatment.
Area of Science:
- Nephrology
- Hepatology
- Internal Medicine
Background:
- Hepatorenal syndrome (HRS) is a severe complication of advanced liver disease.
- It presents as functional renal impairment due to circulatory changes.
- HRS is a diagnosis of exclusion with a variable prognosis.
Purpose of the Study:
- To provide a comprehensive review of hepatorenal syndrome (HRS).
- To elucidate the epidemiology, pathophysiology, diagnosis, and management of HRS.
- To highlight key milestones and advance current understanding of HRS.
Main Methods:
- Targeted literature review.
- Synthesis of existing research on HRS.
- Analysis of diagnostic criteria and treatment strategies.
Main Results:
- HRS pathophysiology involves renal vasoconstriction secondary to systemic vasodilation.
- Current classifications aid in diagnosis and management.
- Prompt diagnosis and treatment are crucial for improving outcomes.
Conclusions:
- Understanding HRS epidemiology and pathophysiology is key.
- Effective management relies on accurate diagnosis and timely intervention.
- Further research is needed to improve HRS prognosis.
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