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Adjunctive rifampin therapy for native valve Staphylococcus aureus endocarditis in a neonate: A case report and

Mohammed A Almatrafi1,2, Nouf Alsahaf3, Elaf J Alsharif2

  • 1Department of Pediatrics Umm Al Qura University Makkah Saudi Arabia.

Clinical Case Reports
|October 11, 2021
PubMed

Insights

Neonatal infective endocarditis is dangerous. Adding rifampin to standard treatment helped a critically ill infant with Staphylococcus aureus native valve endocarditis recover.

Area of Science:

  • Neonatal medicine
  • Cardiology
  • Infectious diseases

Background:

  • Infective endocarditis (IE) poses a significant threat to neonates.
  • Staphylococcus aureus is a common cause of native valve endocarditis (NVE).
  • Salvage therapy is crucial for critically ill neonates with NVE.

Observation:

  • A case of a full-term neonate diagnosed with Staphylococcus aureus NVE was reported.
  • The neonate presented with a severe clinical condition requiring intensive care.

Findings:

  • Adjunctive rifampin therapy was added to the standard treatment regimen.
  • The neonate experienced a favorable clinical outcome following the addition of rifampin.

Implications:

  • Rifampin may be a valuable component of salvage therapy for neonatal NVE.
  • This case highlights a potential therapeutic strategy for severe Staphylococcus aureus infections in neonates.
  • Further research is warranted to confirm the efficacy of rifampin in this population.

Keywords:
infective endocarditisneonatalrifampin

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