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Related Experiment Video

Updated: Oct 17, 2025

Capillary-based Centrifugal Microfluidic Device for Size-controllable Formation of Monodisperse Microdroplets

Capillary-based Centrifugal Microfluidic Device for Size-controllable Formation of Monodisperse Microdroplets

Published on: February 22, 2016

Sequential storage and release of microdroplets.

Zenon Toprakcioglu¹, Tuomas P J Knowles^1,2

¹Centre for Misfolding Diseases, Yusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW UK.

Microsystems & Nanoengineering

|October 11, 2021

Summary

This summary is machine-generated.

This study introduces a microfluidic device that generates, traps, and releases microdroplets sequentially. This innovation enables on-chip analysis and off-chip retrieval for further study, advancing droplet microfluidics.

Keywords:

Chemistry Engineering

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Capillary-based Centrifugal Microfluidic Device for Size-controllable Formation of Monodisperse Microdroplets

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Generation of Size-controlled Poly ethylene Glycol Diacrylate Droplets via Semi-3-Dimensional Flow Focusing Microfluidic Devices

Generation of Size-controlled Poly ethylene Glycol Diacrylate Droplets via Semi-3-Dimensional Flow Focusing Microfluidic Devices

Published on: July 3, 2018

Area of Science:

Microfluidics
Analytical Chemistry
Biotechnology

Background:

Droplet microfluidics enables high-throughput analysis at low volumes.
Trapping microdroplets is crucial for observation but recovery is challenging.
Existing methods lack efficient droplet retrieval for further analysis.

Purpose of the Study:

To develop a microfluidic device for sequential generation, confinement, and release of microdroplets.
To investigate the critical parameters for successful droplet storage and retrieval.
To enable both on-chip monitoring and off-chip collection of microdroplets.

Main Methods:

Experimental microfluidic device fabrication and testing.
Computational simulations to understand droplet behavior.
Analysis of continuous phase flow rate effects on droplet release.

Main Results:

A novel device design for sequential microdroplet manipulation was demonstrated.
Key features for droplet storage and retrieval were identified through simulations and experiments.
A critical flow rate of the continuous phase was found necessary for complete droplet release.
Released droplets were successfully retrieved and collected off-chip.

Conclusions:

The developed device allows for controlled generation, storage, and sequential release of microdroplets.
This capability facilitates on-chip reaction monitoring and off-chip sample retrieval for advanced analysis.
The technology opens new avenues in analytical chemistry and biology through enhanced droplet microfluidic applications.