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The renin-angiotensin system, mood, and suicide: Are there associations?

Marsal Sanches1, Antonio Lucio Teixeira2

  • 1UT Center of Excellence on Mood Disorders, Department of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center at Houston, Houston, TX 77054, United States. marsal.sanches@uth.tmc.edu.

World Journal of Psychiatry
|October 11, 2021
PubMed

Insights

The renin-angiotensin system (RAS) may play a role in mood disorders and suicide. Research suggests a link between RAS dysfunction and suicidal behavior, but more study is needed to understand the exact mechanisms.

Area of Science:

  • Neuroscience
  • Psychiatry
  • Endocrinology

Background:

  • The renin-angiotensin system (RAS) is a key hormonal system involved in blood pressure regulation.
  • Emerging evidence suggests a potential role for the RAS in the neurobiology of mood disorders and suicidal behavior.

Purpose of the Study:

  • To critically analyze existing literature on the association between the renin-angiotensin system and suicidal behavior.
  • To discuss the pathophysiological hypotheses linking RAS dysfunction to suicide.

Main Methods:

  • Literature review and critical analysis of epidemiological, genetic, and biochemical findings.
  • Discussion of proposed pathophysiological mechanisms.

Main Results:

  • Available evidence supports the involvement of the RAS in the neurobiology of suicide.
  • Specific mechanisms linking RAS to suicidal behavior remain to be elucidated.

Conclusions:

  • The renin-angiotensin system is implicated in the pathophysiology of suicide.
  • Further research is required to fully understand the underlying mechanisms and therapeutic implications.
Keywords:
Bipolar disorderDepressionMood disordersRenin-angiotensin systemSuicide

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