Related Experiment Video
Updated: Oct 17, 2025

Effects of Mechanical Methods Used in Peri-implantitis Treatment on Implant Surface Decontamination and Roughness
Published on: March 14, 2025
Voriconazole-associated periostitis: Pathophysiology, risk factors, clinical manifestations, diagnosis, and
Anthony J Guarascio1, Nitin Bhanot2, Zaw Min3
1Department of Pharmacy, Duquesne University School of Pharmacy, Pittsburgh, PA 15282, United States.
Abstract:
Voriconazole use has been associated with osteoarticular pain and periostitis, likely due to high fluoride content in the drug formulation. This phenomenon has been described primarily with high dosage or prolonged course of voriconazole therapy in immunocompromised and transplant patient populations. Patients typically present with diffuse bony pains associated with elevated serum alkaline phosphatase and plasma fluoride levels in conjunction with radiographic findings suggestive of periostitis. We provide a comprehensive review of the literature to highlight salient characteristics commonly associated with voriconazole-induced periostitis.
Related Concept Videos
Acute Pancreatitis II: Clinical Manifestations and Management
Pericarditis IV: Nursing Management
Pericarditis III: Medical Management
Barrett Esophagus-II: Clinical Manifestations and Management
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
Gastritis III: Clinical Manifestations and Management
Clinical manifestations of acute gastritis
The patient with acute gastritis may have a rapid onset of symptoms, such as epigastric pain or discomfort, dyspepsia, anorexia, hiccups, or nausea and vomiting, which can last from a few hours to a few days. Erosive or hemorrhagic gastritis may cause bleeding, which may manifest as blood in vomit or as...
Endocarditis IV: Nursing Management

